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2010 Fiscal Year Final Research Report

Development of high-speed and high-efficiency monolithic silica capillary columns for high-performance liquid chromatography

Research Project

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Project/Area Number 20350036
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionKyoto Institute of Technology

Principal Investigator

TANAKA Nobuo  Kyoto Institute of Technology, 法人本部, 学長特任補佐 (60127165)

Co-Investigator(Kenkyū-buntansha) IKEGAMI Tohru  京都工芸繊維大学, 工芸科学研究科, 准教授 (20301252)
Project Period (FY) 2008 – 2010
KeywordsHPLC / モノリスカラム / シリカ / キャピラリー / 高性能化 / 理論段数 / ピークキャパシティ / ナノHPLC
Research Abstract

Optimization of preparation conditions of monolithic silica capillary columns attained 10000 and 1000000 theoretical plates with a column dead time of 10s and 5000s, respectively, providing ultrahigh resolution of closely related substances.

  • Research Products

    (36 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (16 results) Book (7 results) Remarks (2 results)

  • [Journal Article] Monolithic silica rod columns for high-efficiency reversed-phase liquid chromatography.2011

    • Author(s)
      S.Miyazaki, M.Takahashi, M.Ohira, H.Terashima, K.Morisato, K.Nakanishi, T.Ikegami, K.Miyabe, N.Tanaka, J.Chromatogr.A
    • Journal Title

      1218

      Pages: 1988-1994

    • Peer Reviewed
  • [Journal Article] One-Dimensional Capillary Liquid Chromatographic Separation Coupled with Tandem Mass Spectrometry Unveils the Escherichia coli Proteome on a Microarray Scale.2010

    • Author(s)
      M.Iwasaki, S.Miwa, T.Ikegami, M.Tomita, N.Tanaka, Y.Ishihama, Anal.Chem.
    • Journal Title

      82

      Pages: 2616-2620

    • Peer Reviewed
  • [Journal Article] Test compounds for detecting the silanol effect on the elution of ionized amines in reversed-phase LC.2010

    • Author(s)
      K.Okusa, Y.Suita, Y.Otsuka, M.Tahara, T.Ikegami, N.Tanaka, M.Ohira, M.Takahashi, J.Sep.Sci.
    • Journal Title

      33

      Pages: 348-358

    • Peer Reviewed
  • [Journal Article] The performance of hybrid monolithic silica capillary columns prepared by changing feed ratios of tetramethoxysilane and methyltrimethoxysilane2010

    • Author(s)
      T.Hara, S.Makino, Y.Watanabe, T.Ikegami, K.Cabrera, B.Smarsly, N.Tanaka, J.Chromatogr.A
    • Journal Title

      1217

      Pages: 89-98

    • Peer Reviewed
  • [Journal Article] Improvement of separation efficiencies of anion-exchange chromatography using monolithic silica capillary columns modified with polyacrylates and polymethacrylates containing tertiary amino or quaternary ammonium groups.2009

    • Author(s)
      Y.Watanabe, T.Ikegami, K.Horie, T.Hara, J.Jaafar, N.Tanaka, J.Chromatogr.A
    • Journal Title

      1216

      Pages: 7394-7401

    • Peer Reviewed
  • [Journal Article] Selectivity comparisons of monolithic silica capillary columns modified with poly(octadecyl methacrylate) and octadecyl moieties for halogenated compounds in reversed-phase liquid chromatography.2009

    • Author(s)
      W.Soonthorntantikul, N.Leepipatpiboon, T.Ikegami, N.Tanaka, T.Nhujak, J.Chromatogr.A
    • Journal Title

      1216

      Pages: 5868-5874

    • Peer Reviewed
  • [Journal Article] Preparation of monolithic silica columns for high-performance liquid chromatography.2008

    • Author(s)
      O.Nunez, K.Nakanishi, N.Tanaka, J.Chromatogr.A
    • Journal Title

      1191

      Pages: 231-252

    • Peer Reviewed
  • [Journal Article] Separation efficiencies in hydrophilic interaction chromatography2008

    • Author(s)
      T.Ikegami, K.Tomomatsu, H.Takubo, K.Horie, N.Tanaka, J.Chromatogr.A
    • Journal Title

      1184

      Pages: 474-503

    • Peer Reviewed
  • [Journal Article] High-efficiency liquid chromatographic separation utilizing long monolithic silica capillary columns.2008

    • Author(s)
      K.Miyamoto, T.Hara, H.Kobayashi, H.Morisaka, D.Tokuda, K.Horie, K.Koduki, S.Makino, O.Nunez, C.Yang, T.Kawabe, T.Ikegami, H.Takubo, Y.Ishihama, N.Tanaka, Anal.Chem.
    • Journal Title

      80

      Pages: 8741-8750

    • Peer Reviewed
  • [Journal Article] Anion exchange silica monolith for capillary liquid chromatography2008

    • Author(s)
      J.Jaafar , Y.Watanabe, T.Ikegami, K.Miyamoto, N.Tanaka, Anal.Bioanal.Chem
    • Journal Title

      391

      Pages: 2551-2556

    • Peer Reviewed
  • [Journal Article] Highly efficient analysis of underivatized carbohydrates using monolithic-silica-based capillary hydrophilic interaction (HILIC) HPLC.2008

    • Author(s)
      T.Ikegami, K.Horie, N.Saad, K.Hosoya, O.Fiehn, N.Tanaka, Anal.Bioanal.Chem.
    • Journal Title

      391

      Pages: 2533-2542

    • Peer Reviewed
  • [Presentation] High-efficiency monolithic silica columns for HPLC.2011

    • Author(s)
      田中信男
    • Organizer
      Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy.
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2011-03-15
  • [Presentation] モノリス型シリカカラムのクロマトグラフィー特性2010

    • Author(s)
      田中信男
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      Sendai
    • Year and Date
      2010-09-15
  • [Presentation] Monolithic silica columns for high-speed and high-efficiency HPLC Separations.2010

    • Author(s)
      田中信男
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques.
    • Place of Presentation
      Boston, USA
    • Year and Date
      2010-06-20
  • [Presentation] HPLCカラムの高性能化2009

    • Author(s)
      田中信男
    • Organizer
      第20回クロマトグラフィー科学会議
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-11-12
  • [Presentation] High-efficiency monolithic silica capillary columns for micro-HPLC.2009

    • Author(s)
      田中信男
    • Organizer
      24th International Symposium on MicroScale Bioseparations.
    • Place of Presentation
      Dalian, China.
    • Year and Date
      2009-10-22
  • [Presentation] High-efficiency monolithic silica columns for HPLC.2009

    • Author(s)
      田中信男
    • Organizer
      34th International Symposium on High Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2009-07-01
  • [Presentation] Preparation and evaluation of monolithic silica columns for hydrophilic interaction (HILIC) chromatography.2008

    • Author(s)
      Tohru Ikegami, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-04
  • [Presentation] Study of peak capacity utilizing monolithic silica capillary columns in liquid chromatography - mass spectrometry.2008

    • Author(s)
      Hirotaka Takubo, Tohru Ikegami, Nobuo Tanaka, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-03
  • [Presentation] Development of high-efficiency ion-exchange monolithic silica columns.2008

    • Author(s)
      Yuta Watanabe, Tohru Ikegami, Nobuo Tanaka, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques.
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-03
  • [Presentation] Preparation of monolithic silica capillary columns for chiral separation by on-column polymerization, and the evaluation of their separation efficiency.2008

    • Author(s)
      Tohru Ikegami, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques.
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-03
  • [Presentation] Selectivity comparison of monolithic silica capillary columns modified with poly(octadecyl methacrylate) and octadecyl moiety for halogenated compounds in reversed-phase HPLC.2008

    • Author(s)
      Thumnoon NHUJAK, Tohru Ikegami, Nobuo Tanaka, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques.
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-03
  • [Presentation] Two-dimensional capillary HPLC in a reversed-phase mode using two C18 monolithic silica columns modified with octadecyl moiety and poly(octadecyl methacrylate).2008

    • Author(s)
      Thumnoon NHUJAK, Tohru Ikegami, Nobuo Tanaka, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques.
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-03
  • [Presentation] High efficiency monolithic silica capillary columns for micro-HPLC.2008

    • Author(s)
      田中信男, 他
    • Organizer
      Asia-Pacific International Symposium on Microscale Separations and Analysis
    • Place of Presentation
      Kaoshung, ROC Taiwan.
    • Year and Date
      2008-11-03
  • [Presentation] Two-dimensional capillary HPLC in a reversed-phase mode using two monolithic silica C18 columns modified with octadecylsilyl- (N,N- diethylamino)silane and poly(octadecyl methacrylate.2008

    • Author(s)
      Thumnoon NHUJAK, Tohru Ikegami, Nobuo Tanaka, 他.
    • Organizer
      International Symposium on Chromatography
    • Place of Presentation
      Munster, Germany.
    • Year and Date
      2008-09-22
  • [Presentation] High performance monolithic silica columns for reversed-phase, HILIC, and ion-exchange mode HPLC.2008

    • Author(s)
      田中信男, 他
    • Organizer
      19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA2008)
    • Place of Presentation
      Gdansk, Poland.
    • Year and Date
      2008-06-09
  • [Presentation] High-efficiency liquid chromatographic separation utilizing long monolithic silica capillary columns.2008

    • Author(s)
      田中信男, 他
    • Organizer
      International Symposium on High Performance Liquid Phase Separations and Related Techniques.
    • Place of Presentation
      Baltimore, USA.
    • Year and Date
      2008-05-12
  • [Book] Monolithic Silicas in Separation Science(The basic idea and the drivers.)2011

    • Author(s)
      N.Tanaka, K.K.Unger, Ed.K.K.Unger, N.Tanaka, E.Machtejevas
    • Total Pages
      1-5
    • Publisher
      Wiley
  • [Book] Monolithic Silicas in Separation Science(Preparation and properties of various types of monolithic silica stationary phases for reversed-phase, hydrophilic interaction, and ion-exchange chromatography based on polymer-coated materials.)2011

    • Author(s)
      O.Nunez, T.Ikegami, Ed.K.K.Unger, N.Tanaka, E.Machtejevas
    • Total Pages
      35-45
    • Publisher
      Wiley
  • [Book] In "Monolithic Silicas in Separation Science"(High-speed and high-efficiency separations by utilizing monolithic silica capillary columns.)(E.Machtejeves, N.Tanaka, K.K.Unger, ed.)2011

    • Author(s)
      T.Hara, K.Miyamoto, S.Makino, S.Miwa, M.Ohira, N.Tanaka
    • Total Pages
      249-269
    • Publisher
      Wiley
  • [Book] Frontiers in Chemistry((In Japanese) High-speed and high-efficiency HPLC separations by using monolithic silica columns.)(T.Kitamori, Ed.)2008

    • Author(s)
      N.Tanaka
    • Total Pages
      43-51
    • Publisher
      Kagaku Dojin.
  • [Book] Multidimensional Liquid Chromatography : Theory and Applications in Industrial Chemistry and the Life Sciences(Monolithic columns and their 2D-HPLC applications.)(S.Cohen and M.Schure Ed.)ISBN:978-0-471-73847-32008

    • Author(s)
      T.Ikegami, H.Aoki, H.Kimura, K.Hosoya, N.Tanaka
    • Total Pages
      147-176
    • Publisher
      John and Wiley and Sons.
  • [Book] Multidimensional Liquid Chromatography : Theory and Applications in Industrial Chemistry and the Life Sciences(Monolithic columns and their 2D-HPLC applications.)2008

    • Author(s)
      T.Ikegami, N.Tanaka, et al.
    • Total Pages
      147-176
    • Publisher
      John and Wiley and Sons.
  • [Book] In "Extreme Chromatography : Faster, Hotter, Smaller" (High-efficiency liquid chromatography separations achieved by monolithic silica columns.)(W.C.Byrdwell and M.Holcapek, ed.)

    • Author(s)
      K.Miyamoto, T.Ikegami, T.Hara, Y.Ishihama, N.Tanaka
    • Publisher
      AOCS Press.In press.
  • [Remarks] ホームページ等

    • URL

      http://repository.lib.kit.ac.jp/dspace/handle/10212/1960

  • [Remarks] 田中信男HPLC分離カラム開発と精密分離

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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