2010 Fiscal Year Final Research Report
Development of Efficient Catalytic Processes toward Functional Molecules Synthesis
| Project/Area Number |
20350045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University (2009-2010)
Tokyo Institute of Technology (2008) |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | 多成分カップリングプロセス |
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| Research Abstract |
Novel transition-metal-catalyzed coupling processes have been developed and they have been applied to the concise syntheses of biologically active compounds. These studies include the ruthenium-catalyzed cyclizations of diynes, the copper-catalyzed hydroarylations of electron-deficient alkynes, the palladium-catalyzed alkoxycarbonylation of arylboronates, etc. and the constructions of molecular framworks of natural products and drugs have been achieved using these processes.
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[Remarks] Naohiro Kirai, Yoshihiko Yamamoto, STEREOSELECTIVE SYNTHESIS OF 3-ARYLACRYLATES BY COPPER-CATALYZED SYN HYDROARYLATION[(E)-Methyl 3-phenyloct-2-enoate], Organic Syntheses, 87巻, 2009, 53-58.
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[Remarks] Yoshihiko Yamamoto, Chloro[(1, 2, 5, 6-η)-1, 5-cyclooctadiene][(1, 2, 3, 4, 5-η)-1, 2, 3, 4, 5-pentamethyl-2, 4-cyclopentadien-1-yl] ruthenium, Electronic Encyclopedia of Reagents for Organic Synthesis, Wiley, 2009.
