2010 Fiscal Year Final Research Report
Synthesis and Molecule-Capturing Dynamics of Protein Nanotubes Having Size Control Ability of the Inner Pore
| Project/Area Number |
20350058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Chuo University (2010)
Waseda University (2008-2009) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Akito 早稲田大学, 理工学術院, 講師 (20348858)
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| Research Collaborator |
QU Xue , 日本学術振興会外国人研究員
STEPHEN Curry Imperial College London, 教授
AZUMA Hiroshi 北海道赤十字血液センター, 研究部, 部長
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| Project Period (FY) |
2008 – 2010
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| Keywords | 高分子錯体 / ナノチューブ / 蛋白質 / 分子包接 / 超分子 / アルブミン / 交互積層 |
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| Research Abstract |
We prepared novel bionanotubes composed of proteins and succeeded to capture desired molecules and target biopolymers into their cylindrical walls and one-dimensional pore space interior.(i) Compositions, structures, and preparation conditions of the nanotubes,(ii) 3D structures and pore-size controls,(iii) molecule-capturing to the tubular walls and inner pores, and(iv) biopolymer-capturing into the channels were clarified. These results were published as 17 research papers. Virus trap nanotubes were highlighted by Chemistry World(Royal Society of Chemistry) and are attracted considerable attention.
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[Remarks] 研究代表者が中央大学へ異動(平成22年度)したのを契機に、中央大学理工学部応用化学科のwebサイトに「小松研究室」ホームページ(日本語版と英語版)を開設、本研究で得られた成果を広く世界に向けて発信している。
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[Remarks] Chemistry World(Royal Society of Chemistry), 2011, February. "Protein nanotubes traps viruses"
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[Remarks] 高分子, 2008, 57, 740(Hot Topics)"Template Synthesis of Protein Nanotubes"
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[Remarks] 高分子, 2008, 57, 55(Hot Topics)"Functional Protein Nanotubes"
