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2012 Fiscal Year Final Research Report

Preparation of Metal-coated Liposomes"Metallosomes"and Their Manipulation Function

Research Project

  • PDF
Project/Area Number 20350080
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionNara Institute of Science and Technology

Principal Investigator

KIKUCHI Jun-ichi  奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (90153056)

Co-Investigator(Kenkyū-buntansha) YASUHARA Kazuma  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (90545716)
TAHARA Keishiro  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50622297)
Project Period (FY) 2008 – 2012
Keywords自己組織化 / 超薄膜・複合ナノ材料 / 人工細胞膜 / メタロソーム / セラソーム / 無電解めっき / マニピュレーション機能
Research Abstract

In this study, we designed artificial cell membranes coated with ultrathin metallic layer as a novel hybrid nanomaterial. Themetal-coated liposomal membraneswereprepared by adopting electroless plating technique on the cerasomes as highly stable artificial cell membranes developed by us. We also clarified characteristic manipulation behaviorof artificial cell membranes having vesicular or disk-like structure, based on the molecular recognition functionally introduced into the membranes.

  • Research Products

    (41 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 16 results) Presentation (20 results) Book (3 results)

  • [Journal Article] Spontaneously Formed Semipermeable Organic-Inorganic Hybrid Vesicles Permitting Molecular Weight Selective Transmembrane Passage2013

    • Author(s)
      K. Yasuhara, T. Kawasaki, S. Okuda, S. Oshima, J. Kikuchi
    • Journal Title

      Chem. Commun

      Volume: 49(7) Pages: 665-667

    • DOI

      DOI: 10.1039/c2cc36662b

    • Peer Reviewed
  • [Journal Article] Thermal Stability of Synthetic Lipid Bicelles Encompassed by Siloxane Surfaces as Organic-Inorganic Hybrid Nanodiscs2012

    • Author(s)
      K. Yasuhara, H. Hayashi J. Kikuchi
    • Journal Title

      Chem. Lett

      Volume: 41(10) Pages: 1223-1225

    • DOI

      DOI: 10.1246/cl.2012.1223

    • Peer Reviewed
  • [Journal Article] Intermolecular Communication on a Liposomal Membrane. Enzymatic Amplification of a Photonic Signal with Gemini Peptide Lipid as a Membrane-bound Artificial Receptor2012

    • Author(s)
      M. Mukai, K. Maruo, Y. Sasaki, J. Kikuchi
    • Journal Title

      Chem. Eur. J

      Volume: 18(11) Pages: 3258-3263

    • DOI

      DOI: 10.1002/chem.201103552

    • Peer Reviewed
  • [Journal Article] バイオ・ナノハイブリッドマテリアルの創成と分子通信デバイスとしての可能性2012

    • Author(s)
      菊池純一
    • Journal Title

      化学工業

      Volume: 63(3) Pages: 182-187

    • URL

      http://www.kako-sha.co.jp/

  • [Journal Article] Liposomal Architecture Boosts Biocompatibility of Nanohybrid Cerasomes2011

    • Author(s)
      Y. Ma, Z. Dai, Y. Gao, Z. Cao, Z. Zha, X. Yue, J. Kikuchi
    • Journal Title

      Nanotoxicology

      Volume: 5(4) Pages: 622-635

    • DOI

      DOI: 10.3109/17435390.2010.546950

    • Peer Reviewed
  • [Journal Article] Remarkable Long-Term Stability of Cerasome as an Organic-Inorganic Hybrid Nano-Container for Water-Soluble Macromolecules2011

    • Author(s)
      T. Kawataki, K. Yasuhara, J. Kikuchi
    • Journal Title

      Chem. Lett

      Volume: 40(5) Pages: 461-463

    • DOI

      DOI: 10.1246/cl.2011.461

    • Peer Reviewed
  • [Journal Article] Photoresponsive Liposomal Nanohybrid Cerasomes2011

    • Author(s)
      X. Liang, X. Yue, Z. Dai, J. Kikuchi
    • Journal Title

      Chem. Commun

      Volume: 47(16) Pages: 4751-4753

    • DOI

      DOI: 10.1039/c1cc00063b

    • Peer Reviewed
  • [Journal Article] Specific Delivery of Transport Vesicles Mediated by Complementary Recognition of DNA Signals with Membrane-bound Oligonucleotide Lipids2011

    • Author(s)
      K. Yasuhara, Z. Wang, T. Ishikawa, J. Kikuchi, Y. Sasaki, S. Hiyama, Y. Moritani,T. Suda
    • Journal Title

      Supramol. Chem

      Volume: 23(3-4) Pages: 218-225

    • DOI

      DOI: 10.1080/10610278.2010.521835

    • Peer Reviewed
  • [Journal Article] Switching of the Enzymatic Activity Synchronized with Signal Recognition by an Artificial DNA Receptor on a Liposomal Membrane2011

    • Author(s)
      Y. Sasaki, M. Mukai, A. Kawasaki, K. Yasuhara, J. Kikuchi
    • Journal Title

      Org. Biomol. Chem

      Volume: 9(7) Pages: 2397-2402

    • DOI

      DOI: 10.1039/c0ob00918k

    • Peer Reviewed
  • [Journal Article] Synthesis of Organic-Inorganic Hybrid Bicelles Lipid Bilayer Nanodiscs Encompassed by Siloxane Surfaces2011

    • Author(s)
      K. Yasuhara, S. Miki, H. Nakazono, A. Ohta, J. Kikuchi
    • Journal Title

      Chem. Commun

      Volume: 47(16) Pages: 4691-4692

    • DOI

      DOI: 10.1039/c1cc10254k

    • Peer Reviewed
  • [Journal Article] Stabilized Liposomal Nanohybrid Cerasomes for Drug Delivery Applications2010

    • Author(s)
      Z. Cao, Y. Ma, X. Yue, S. Li, Z. Dai, J. Kikuchi
    • Journal Title

      Chem. Commun

      Volume: 46(29) Pages: 5265-5267

    • DOI

      DOI: 10.1039/b926367e

    • Peer Reviewed
  • [Journal Article] Effects of Surface Carboxylic Acid Groups of Cerasomes, Morphologically Stable Vesicles Having a Silica Surface, on Biomimetic Deposition of Hydroxyapatite in Body Fluid Conditions2010

    • Author(s)
      M. Hashizume, H. Horii, J. Kikuchi, M. Kamitakahara, C. Ohtsuki, M. Tanihara
    • Journal Title

      J. Mater. Sci.: Mater. Med

      Volume: 12(1) Pages: 11-19

    • DOI

      DOI: 10.1007/s10856-009-3829-7

    • Peer Reviewed
  • [Journal Article] Propagation and Amplification of Molecular Information using a Photo-responsive Molecular Switch2009

    • Author(s)
      M. Mukai, K. Maruo, J. Kikuchi, Y. Sasaki, S. Hiyama, Y. Moritani, T. Suda
    • Journal Title

      Supramol. Chem

      Volume: 21(3-4) Pages: 284-291

    • DOI

      DOI: 10.1080/10610270802468439

    • Peer Reviewed
  • [Journal Article] Efficient Fluorescence Resonance Energy Transfer in Highly Stable Liposomal Nanohybrid Cerasome2009

    • Author(s)
      Z.-F. Dai, W.-J. Tian, X.-L. Yue, Z.-Z. Zheng, J.-J. Qi, N. Tamai, J. Kikuchi
    • Journal Title

      Chem. Commun

      Volume: 15 Pages: 2032-2034

    • DOI

      DOI: 10.1039/b900051h

    • Peer Reviewed
  • [Journal Article] ハイブリッド人工細胞「セラソーム」の創成とその展開2008

    • Author(s)
      菊池純一
    • Journal Title

      未来材料

      Volume: 8(6) Pages: 51-57

    • URL

      http://www.nts-book.co.jp/mirai/bn2008.html

  • [Journal Article] DNAをテンプレートとしたセラソーム集積構造の構築2008

    • Author(s)
      橋詰峰雄, 佐々木善浩, 寺島崇, 小松孝禎, 菊池純一
    • Journal Title

      高分子論文集

      Volume: 65(6) Pages: 421-426

    • URL

      http://dx.doi.org/10.1295/koron.65.421

    • Peer Reviewed
  • [Journal Article] Creation of Magnetic Cerasomes through Electroless Plating and Their Manipulation Using External Magnetic Fields2008

    • Author(s)
      D. Minamida, S. Okada, M. Hashizume, Y. Sasaki, J. Kikuchi, N. Hosoito, T. Imori
    • Journal Title

      J. Sol-Gel Sci. Technol

      Volume: 48(1-2) Pages: 95-101

    • DOI

      DOI: 10.1007/s10971-008-1757-5

    • Peer Reviewed
  • [Journal Article] A Nano Sensory Device Fabricated on a Liposome for Detection of Chemical Signals

    • Author(s)
      Y. Sasaki, Y. Shioyama, W.-J. Tian, J. Kikuchi, S. Hiyama, Y. Moritani, T. Suda
    • Journal Title

      Biotechnol. Bioeng

      Volume: 105(1) Pages: 37-43

    • DOI

      DOI: 10.1002/bit.22521

    • Peer Reviewed
  • [Presentation] 有機-無機ハイブリッドベシクルの分子ふるい機能とバイオナノリアクターへの応用2013

    • Author(s)
      安原主馬, 大島匠平, 菊池純一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀県草津市
    • Year and Date
      2013-03-23
  • [Presentation] Cerasomes as an Organic-Inorganic Nanohybrid Material2012

    • Author(s)
      J. Kikuchi
    • Organizer
      The International Symposium on Preparative Chemistry of Advanced Materials 2012
    • Place of Presentation
      Shenyang, P.R. China
    • Year and Date
      2012-09-14
  • [Presentation] セラソームの半透膜機能とその制御2012

    • Author(s)
      安原主馬, 奥田静代, 大島匠平, 菊池純一
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2012-05-29
  • [Presentation] Organic-Inorganic Hybrid Bicelles: Lipid Bilayer Nanodiscs Stabilized with Siloxane Surface2012

    • Author(s)
      K. Yasuhara, H. Hayashi, S. Kitazato, J. Kikuchi
    • Organizer
      International Association of Colloid and Interface Scientists (2012)
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2012-05-14
  • [Presentation] 脂質二分子膜を有する有機-無機ハイブリッドナノディスクの形成とバイオ応用2011

    • Author(s)
      安原主馬, 林宏樹, 中園元, 菊池純一
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2011-09-12
  • [Presentation] Organic- Inorganic Hybrid Bicelles as Supramolecular Scaffolds for Reconstitution of Membrane Proteins2011

    • Author(s)
      K. Yasuhara, J. Kikuchi
    • Organizer
      6th International Symposium on Macrocyclic and Supramolecular Chemistry
    • Place of Presentation
      Brighton, UK
    • Year and Date
      2011-07-03
  • [Presentation] Cerasomes: A New Family of Artificial Cell Membranes with Ceramic Surface2011

    • Author(s)
      J. Kikuchi
    • Organizer
      26th Philippine Chemistry Congress
    • Place of Presentation
      Cebu, Philippine
    • Year and Date
      2011-04-13
  • [Presentation] Fabrication of Well-defined Organic- Inorganic Hybrid Nanodiscs by the Self-assembly of Organoalkoxysylane Lipid2010

    • Author(s)
      K. Yasuhara, S. Miki, J. Kikuchi
    • Organizer
      The 2011 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-16
  • [Presentation] Self-assembly Directed Formation of Lipid Bilayer Nanodiscs Stabilized by Siloxane Network2010

    • Author(s)
      H. Nakazono, S. Miki, K. Yasuhara, J. Kikuchi
    • Organizer
      18th International Symposium on Surfactants in Solution
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-11-16
  • [Presentation] Formation of Organic-Inorganic Hybrid Bicelles and Their Characteristics2010

    • Author(s)
      K. Yasuhara, S. Miki, J. Kikuchi
    • Organizer
      International Conference on Nanoscopic Colloid and Surface Science
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2010-09-20
  • [Presentation] Metallosomes: Nanohybrid Vesicles with Organic2010

    • Author(s)
      J. Kikuchi, K. Yasuhara, K. Xu, T. Kawataki
    • Organizer
      Ceramic and Metallic Layers, International Conference on Science and Technology of Synthetic Metals 2010
    • Place of Presentation
      京都府京都市
    • Year and Date
      2010-07-08
  • [Presentation] Bio-inspired Molecular Communication System Based on Molecular Recognition on Artificial Cell Membrane2010

    • Author(s)
      K. Yasuhara, J. Kikuchi
    • Organizer
      5th International Symposium on Macrocyclic and Supramolecular Chemistry
    • Place of Presentation
      奈良県奈良市
    • Year and Date
      2010-06-09
  • [Presentation] シグナル応答性分子スイッチを用いる人工膜輸送システム2009

    • Author(s)
      王忠華, 伊藤裕志, 安原主馬, 菊池純一
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2009-09-17
  • [Presentation] 自己組織化による有機無機ハイブリッドナノディスクの形成2009

    • Author(s)
      三木章平, 安原主馬, 菊池純一
    • Organizer
      日本ゾル-ゲル学会第7回討論会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2009-07-30
  • [Presentation] Design of an Artificial Membrane Traffic System for Molecular Communication2009

    • Author(s)
      J. Kikuchi, Z.-H. Wang, K. Yasuhara, S. Hiyama, Y. Moritani, T. Suda
    • Organizer
      4th International Symposium on Macrocyclic and Supramolecular Chemistry
    • Place of Presentation
      Maastricht, Netherlands
    • Year and Date
      2009-06-22
  • [Presentation] 人工細胞を用いるメンブレントラフィックシステムの構築2009

    • Author(s)
      菊池純一, 王忠華, 向井理, 安原主馬, 檜山聡, 森谷優貴, 須田達也
    • Organizer
      第5回ホスト・ゲスト化学シンポジウム
    • Place of Presentation
      栃木県宇都宮市
    • Year and Date
      2009-05-30
  • [Presentation] ナノハイブリッド材料としての金属被覆人工細胞膜「メタロソーム」の構造特性2008

    • Author(s)
      菊池純一
    • Organizer
      京都・先端ナノテク総合支援ナノテクシンポジウム
    • Place of Presentation
      奈良県生駒市
    • Year and Date
      2008-12-12
  • [Presentation] 錯体化学とバイオサイエンスの接点-人工細胞膜上での動的錯形成と機能発現-2008

    • Author(s)
      菊池純一
    • Organizer
      九州錯体化学懇談会総設40周年記念シンポジウム
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2008-11-01
  • [Presentation] 金属被覆人工細胞膜「メタロソーム」の構造特性2008

    • Author(s)
      菊池純一, 谷峰, 南田大樹, 伊森徹
    • Organizer
      第3回バイオ関連化学合同シンポジウム
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-09-18
  • [Presentation] 有機-無機-金属ナノハイブリッドベシクル「メタロソーム」の作成と構造変化2008

    • Author(s)
      谷峰, 菊池純一, 伊森徹
    • Organizer
      日本ゾル-ゲル学会第6回討論会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2008-07-31
  • [Book] Transmission Electron Microscopy (TEM), in "Supramolecular Chemistry: From Molecules to Nanomaterials2012

    • Author(s)
      J. Kikuchi, K. Yasuhara
    • Total Pages
      633-645
    • Publisher
      P. A. Gale, J. W. Steed, eds., John Wiley & Sons, Chichester
  • [Book] 三次元集積化ナノハイブリッド材料としてのセラソーム,「ナノハイブリッド材料の開発と応用」2011

    • Author(s)
      橋詰峰雄, 佐々木善浩, 菊池純一
    • Total Pages
      134-144
    • Publisher
      シーエムシー出版
  • [Book] Cerasomes: A New Family of Artificial Cell Membranes with Ceramic Surface, in "Advances in Biomimetics2011

    • Author(s)
      J. Kikuchi, K. Yasuhara
    • Total Pages
      231-250
    • Publisher
      A. George, ed., InTech, Rijeka

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Published: 2014-08-29  

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