2010 Fiscal Year Final Research Report
Study on functionalization of biomaterials by controlling the high order structure
| Project/Area Number |
20350108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
KOBAYASHI Hisatoshi National Institute for Materials Science, 生体材料センター, グループリーダー (90354266)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Chiaki 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10447930)
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| Research Collaborator |
HATTORI Shinya 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, ポスドク研究員 (30469762)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 高分子機能材料 |
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| Research Abstract |
The size of the receptor on the cellular membrane and the recognition of the adhesion molecules are regulated in nanometer order. Therefore it is necessary to design and to control the 3D structure of the materials. In this consequence, we try to understand the real cell recognition mechanism on the functionalized biomaterials by controlling the material nano-micro-macro structure. In this research, we aimed (1) "control of the second/three-dimensional array structure of the fiber" and (2) "three-dimensional structural control of the concentrated polymer brush", and the bodily function characteristic was examined in detail. From the results, the concept of the new type of the tissue engineering scaffolds was developed.
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[Journal Article] Tissue engineering with natural tissue matrices(5th Forum on New Materials, 2010, Part E, Stafa-Zuerich, Switzerland).2010
Author(s)
Kishida A, Funamoto S, Negishi J, Hashimoto Y, Nam K, Kimura T, Fujisato T, Kobayashi H
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Journal Title
Advances in Science and Technology 76
Pages: 125-132
Peer Reviewed
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[Journal Article] Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering.2010
Author(s)
Hashimoto Y, Funamoto S, Sasaki S, Honda T, Hattori S, Nam K, Kimura T, Mochizuki M, Fujisato T, Kobayashi H, et al
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Journal Title
Biomaterials 31(14)
Pages: 3941-3948
Peer Reviewed
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