2011 Fiscal Year Final Research Report
Analysis of molecular recognition in liquid by pulse-modulated attractive force microscopy
| Project/Area Number |
20360020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thin film/Surface and interfacial physical properties
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
TAKAGI Akihiko 大阪大学, 免疫学フロンティア研究センター・企画室, 特任准教授(常勤)
MAEDA Yasushi 産業技術総合研究所, 関西センター・ユビキタスエネルギー研究部門・ナノ材料科学研究グループ, 研究員
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| Project Period (FY) |
2008 – 2011
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| Keywords | 走査プローブ / 分子認識 / 分子電極 / パルス変調 / 水溶液 |
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| Research Abstract |
We revealed that the surface electric-field modulation from the backward electrode of insulating substrate was effective for surface molecular adsorbates. We demonstrated that electrostatic force microscopy gives characteristic contrast inversion between DNA and transcription complex images reflecting the difference of electric polarizability of these molecules. These findings indicate that the electrostatic properties of individual biological molecules can be imaged on an insulator substrate suggesting the basis of pulsed-modulated attractive force microscopy.
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