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2010 Fiscal Year Final Research Report

Modeling, Analysis, and Control for Gene networks

Research Project

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Project/Area Number 20360189
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Control engineering
Research InstitutionTokyo Institute of Technology

Principal Investigator

IMURA Jun-Ichi  Tokyo Institute of Technology, 大学院・情報理工学研究科, 教授 (50252474)

Co-Investigator(Kenkyū-buntansha) IKEDA Tsukasa  宇都宮大学, 工学研究科, 教授 (40151295)
Co-Investigator(Renkei-kenkyūsha) KASHIMA Kenji  東京工業大学, 大学院・情報理工学研究科, 助教 (60401551)
MOROHOSHI Tomohiro  宇都宮大学, 工学研究科, 助教 (90361360)
Project Period (FY) 2008 – 2010
Keywords制御理論 / 遺伝子ネットワーク / ハイブリッドシステム
Research Abstract

In this research project, we have developed a basis on the control theory for gene regulatory networks including modeling (PWA approximation, model reduction etc), scale-free stability analysis for large-scale network systems, and the control synthesis such as optimal control problem, based on experimental aspects of the quorum sensing system of the bacterium Pseudomonas aeruginosa.as well as our previous works on analysis/control synthesis of hybrid dynamical systems.

  • Research Products

    (15 results)

All 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results)

  • [Journal Article] Piecewise affine systems approach to control of biological networks2010

    • Author(s)
      J.Imura, K.Kashima, M.Kusano, T.Ikeda, T.Morohoshi
    • Journal Title

      Philosophical Transactions A 368-1930

      Pages: 4977/4993

    • Peer Reviewed
  • [Journal Article] Local Stability Analysis Of Heterogeneous Equilibrium Patterns Observed In Delta-Notch Signalling Interaction2010

    • Author(s)
      加嶋健司, 井村順一
    • Journal Title

      Journal of the Chinese Institute of Engineers 33-3

      Pages: 347/355

    • Peer Reviewed
  • [Journal Article] スケール変換を介した連続極限解析による大規模カスケードシステムの低次元化2010

    • Author(s)
      石崎孝幸, 加嶋健司, 井村順一
    • Journal Title

      計測自動制御学会論文集 46-10

      Pages: 615/622

    • Peer Reviewed
  • [Journal Article] Regulation of the violacein biosynthetic gene cluster by acylhomoserine lactone-mediated quorum sensing in Chromobacterium violaceum ATCC 124722010

    • Author(s)
      T.Morohoshi, K.Fukamachi, M.Kato, N.Kato, T.Ikeda
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 74

      Pages: 2116/2119

    • Peer Reviewed
  • [Journal Article] AiiM, a novel class of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceum2010

    • Author(s)
      W.Z.Wang, T.Morohoshi, M.Ikenoya, N.Someya, T.Ikeda
    • Journal Title

      Applied and Environmental Microbiology 76

      Pages: 2524/2530

    • Peer Reviewed
  • [Journal Article] Lebesgue piecewise affine approximation of nonlinear systems2010

    • Author(s)
      S.Azuma, J.Imura, T.Sugie
    • Journal Title

      Nonlinear Analysis : Hybrid Systems 4-1

      Pages: 92/102

    • Peer Reviewed
  • [Journal Article] Controlled invariant feasibility-A general approach to enforcing strong feasibility in MPC applied to move-blocking2009

    • Author(s)
      R.Gondhalekar, J.Imura, K.Kashima
    • Journal Title

      Automatica 45-12

      Pages: 2869-2875

    • Peer Reviewed
  • [Journal Article] Novel N-acylhomoserine lactone-degrading bacteria isolated from the leaf surface of Solanum tuberosum and their quorum-quenching propertie2009

    • Author(s)
      T.Morohoshi, N.Someya, T.Ikeda
    • Journal Title

      Biosci. Biotech. Biochem. 73

      Pages: 2124/2127

    • Peer Reviewed
  • [Journal Article] Motility and the expression of the flagellin protein FliC are negatively regulated by quorum sensing in Edwardsiella tarda2009

    • Author(s)
      T.Morohoshi, Y.Yokoyama, M.Ouchi, N.Kato, T.Ikeda
    • Journal Title

      J.Biosci. Bioeng. 108

      Pages: 314/318

    • Peer Reviewed
  • [Presentation] Inhibition of the pathogenicity of Serratia marcescens by the synthetic analog of quorum-sensing signal molecule2010

    • Author(s)
      T.Morohoshi, T.Shiono, K.Takidouchi, N.Kato, T.Ikeda
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-18
  • [Presentation] 状態集約化に基づき特異摂動近似された動的ネットワークシステムの特性解析2010

    • Author(s)
      牟田裕一朗, 石崎孝幸, 加嶋健司, 井村順一
    • Organizer
      第39回制御理論シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-29
  • [Presentation] Control methods of quorum sensing in gram-negative bacteria using cyclodextrins2010

    • Author(s)
      T.Ikeda, S.Ito, T.Morohoshi, N.Kato
    • Organizer
      2010 International Symposium on Advanced Biological Engineering
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-07-24
  • [Presentation] Oscillation Analysis of Linearly Coupled PWA Systems2010

    • Author(s)
      K.Kashima,, Kawamura, J.Imura
    • Organizer
      Proceedings of the 13th ACM International Conference on Hybrid Systems : Computation and Control
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-04-14
  • [Presentation] Inhibition of quorum sensing in gram-negative bacteria using AHL analogues and modified cyclodextrins2009

    • Author(s)
      T.Ikeda, W.Z.Wang, T.Sato, S.Ito, N.Kato, T.Morohoshi
    • Organizer
      Asia Pacific Biochemical Engineering Conference
    • Place of Presentation
      神戸
    • Year and Date
      20091124-20091128
  • [Presentation] Rigorous determination of maximum controlled invariant feasible sets2009

    • Author(s)
      R.Gondhalekar, J.Imura, K.Kashima
    • Organizer
      European Control Conference
    • Place of Presentation
      ブタペスト, ハンガリ
    • Year and Date
      20090823-20090826

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Published: 2012-01-26   Modified: 2016-04-21  

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