2010 Fiscal Year Final Research Report
Regulatory mechanisms of meiotic recombination through movements and morphogenesis of chromosomes
| Project/Area Number |
20370003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
SHINOHARA Akira Osaka University, 蛋白質研究所, 教授 (00252578)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 減数分裂 / 組換え / 染色体 |
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| Research Abstract |
Homologous recombination plays a role in chromosome segregation during meiosis as well as production of genome diversity. Meiotic recombination is coupled with the formation of an unique chromosome structure referred as to the Synaptonemal complex. Not only the formation of the unique chromosome structures, but also meiosis shows chromosome motion and rearrangement of chromosomes inside a nucleus. In this study, we showed that the formation of synaptonemal complex and chromosome motion is regulated by phosphorylation of a nuclear envelope protein, Mps3. This suggests the novel role of nuclear envelop in respect of chromosome functions.
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[Journal Article] Cyclin-dependent kinase (CDK) promotes formation of the synaptonemal complex in yeast meiosis.2010
Author(s)
Zhu, Z., Mori, D., Oshiumi, H., Matsuzaki, K., Shinohara, M., A. Shinohara
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Journal Title
Genes-to-Cells. 15
Pages: 1036-1050
Peer Reviewed
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[Journal Article] Telomeres drive rapid movements regulated by chromosome status in meiotic prophase.2008
Author(s)
Conrad, M.N., Lee, C.-Y., Chao, G., Shinohara, M., Kosaka, H., Shinohara, A., Conchello, J.-A., M. E. Dresser
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Journal Title
Cell. 133
Pages: 1175-1187
Peer Reviewed
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