2010 Fiscal Year Final Research Report
Proton Pumping ATPase and Roles of Acidic pH
| Project/Area Number |
20370048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
FUTAI Masamitsu Iwate Medical University, 薬学部, 教授 (50012646)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Mayumi 岩手医科大学, 薬学部, 准教授 (20270506)
GOTO Naomi (松元 奈緒美) 岩手医科大学, 薬学部, 助教 (80403971)
SEKIYA Mizuki 岩手医科大学, 薬学部, 助教 (70509033)
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| Project Period (FY) |
2008 – 2010
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| Keywords | V-ATPase / F-ATPase / 破骨細胞 / リソソーム / 阻害剤 |
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| Research Abstract |
We have studied rotary mechanism of F-ATPase (ATP synthase) and V-ATPase (lysosome-type ATPase) under the physiological conditions. Significant results were obtained for biochemical and thermodynamic regulatory mechanism. We also studied roles of V-ATPase in vesicle trafficking and formation of osteoclast plasma membrane. Formation of multinuclear cells was studied together with osteoclast differentiation.
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