2010 Fiscal Year Final Research Report
Structure and Function of MBP-ligand oligosaccharides isolated from SW1116 cells
| Project/Area Number |
20370052
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
KAWASAKI Toshisuke Ritsumeikan University, 総合理工学研究機構, 教授 (50025706)
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| Co-Investigator(Kenkyū-buntansha) |
MA BRUCE (ヨン ブルース) 立命館大学, 立命館グローバル・イノベーション研究機構, 准教授 (00378788)
KAWASAKI Nobuko 立命館大学, 総合理工学研究機構, 教授 (70077676)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGURO Masaji 新潟薬科大学, 応用生物科学部, 教授 (10280687)
ISHIDA Hideharu 岐阜大学, 応用生物科学部, 教授 (20203002)
KATO Koichi 名古屋市立大学, 薬学研究科, 教授 (20211849)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌 / 糖鎖 / 先天性免疫 / 動物レクチン / 臨床試料 |
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| Research Abstract |
Based on the biochemical data obtained, we proposed a computer modeling of the molecular complex of the serum mannan-binding protein and its high affinity ligand oligosaccharides on SW1116 cells. Immunohistochemical analysis indicated that the MBP-ligand oligosaccharides are novel tumor marker candidates.
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[Journal Article] Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas2011
Author(s)
Nonaka M, Ma BY, Imaeda H, Kawabe K, Kawasaki N, Hodohara K, Kawasaki N, Andoh A, Fujiyama Y, Kawasaki T
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Journal Title
Peer Reviewed
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[Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW11162009
Author(s)
Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T
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Journal Title
Glycobiology 19
Pages: 437-450
Peer Reviewed
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