2010 Fiscal Year Final Research Report
Novel functions of evolutionarily conserved calpain-7/PalBH in membrane trafficking system.
| Project/Area Number |
20370055
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Tokyo Metropolitan Organization for Medical Research |
|---|
Principal Investigator |
SORIMACHI Hiroyuki Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 (10211327)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ONO Yasuko 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (20392376)
HATA Shoji 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (10392375)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 細胞内タンパク質分解 / カルパイン / カルシウム / 内膜輸送系 |
|---|
| Research Abstract |
Calpains, which are encoded by 15 genes in humans, constitute a family of intracellular Ca^<2+>-dependent proteases. They function to protect living organisms, and, therefore, defects in calpain functions result in lethality or diseases like muscular dystrophy. In this study, we focused on calpain-7/PalBH, which is conserved from human to yeast but has not been studied well so far. As a result, it was suggested that calpain-7 also plays essential roles for mammalian life like calpain-2 and-3.
|
-
[Journal Article] Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations?2011
Author(s)
Saenz A., Ono Y., Sorimachi H., Goicoechea M., Leturcq F., Blazquez L., Garcia-Bragado F., Marina A., Poza J.J., Azpitarte M., Doi N., Urtasun M., Kaplan J.C., Lopez de Munain A.
-
Journal Title
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.2010
Author(s)
Ojima K., Kawabata Y., Nakao H., Nakao K., Doi N., Kitamura F., Ono Y., Hata S., Suzuki H., Kawahara H., Bogomolovas J., Witt C., Ottenheijm C., Labeit S., Granzier H., Toyama-Sorimachi N., Sorimachi M., Suzuki K., Maeda T., Abe K., Aiba A., Sorimachi H.
-
Journal Title
J.Clin.Invest. 120
Pages: 2672-2683
Peer Reviewed
-
-
-
-
-
[Journal Article] Inhibition of calpain increases LIS1(PAFAH1B1) and partially rescues in vivo phenotypes in a mouse model of lissencephaly.2009
Author(s)
Yamada M., Yoshida Y., Mori D., Takitoh T., Kengaku M., Umeshima H., Takao K., Miyakawa T., Sato M., Sorimachi H., Wynshaw-Boris A., Hirotsune S.
-
Journal Title
Nature Med. 15
Pages: 1202-1207
Peer Reviewed
-
-
-
[Journal Article] Multiple molecular interactions implicate connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle.2008
Author(s)
Hayashi C., Ono Y., Doi N., Kitamura F., Tagami M., Mineki R., Arai T., Taguchi H., Yanagida M., Hirner S., Labeit D., Labeit S., Sorimachi H.
-
Journal Title
J.Biol.Chem. 283
Pages: 14801-14814
Peer Reviewed
-
-
[Journal Article] Muscle RING-finger protein MuRF1 as a connector of muscle energy metabolism and protein synthesis.2008
Author(s)
Koyama S., Hata S., Witt C. C., Ono Y., Lerche S., Ojima K., Chiba T., Doi N., Kitamura F., Tanaka K., Abe K., Witt S., Rybin V., Gasch A., Franz T., Labeit S., Sorimachi H.
-
Journal Title
J.Mol.Biol. 376
Pages: 1224-1236
Peer Reviewed
-
-
-
-
[Presentation] Skeletal muscle-specific calpain, p94/calpain-3, dynamically distributes in skeletal muscle cells to adapt to physical stress, defects of which cause muscular dystrophy.2010
Author(s)
Ono Y., Ojima K., Torii F., Takaya E., Doi N., Nakagawa K., Hata S., Abe K., Sorimachi H.
Organizer
15th International Congress of the World Muscle Society
Place of Presentation
Kumamoto, Japan
Year and Date
2010-10-13
-
[Presentation] [Selected for oral presentation] Skeletal muscle-specific calpain, p94/calpain-3, dynamically distributes in skeletal muscle cells to adapt to physical stress, defects of which cause muscular dystrophy.2010
Author(s)
Ojima K., Ono Y., Doi N., Kitamura F., Hata S., Kawabata Y., Suzuki K., Maeda T., Abe K., Nakao H., Aiba A., Nakao K., Suzuki H., Kawahara H., Witt C., Labeit S., Ottenheijm, C., Granzier H., Toyama-Sorimachi N., Sorimachi M., Sorimachi H.
Organizer
15th International Congress of the World Muscle Society
Place of Presentation
Kumamoto, Japan
Year and Date
2010-10-13
-
-
[Presentation] [The closing lecture] In Memoriam Koichi Suzuki : Calpains in muscles and stomach2010
Author(s)
Ono Y., Hata S., Ojima K., Tonami K., Kitamura F., Ueno M., Takaya E., Granzier H., Labeit S., Sorimachi H.
Organizer
12^<th> Symposium on Proteases, Inhibitors and Biological Control
Place of Presentation
Portoroz, Slovenia
Year and Date
2010-09-28
-
-
-
-
-
-
-
[Presentation] Roles of skeletal muscle-specific calpain, p94/calpain 3, on multiple molecular interactions using connectin/titin N2A region as a modulating scaffold.2008
Author(s)
Sorimachi H., Hayashi C., Hata S., Ojima K., Koyama S., Doi N., Kitamura F., Takaya E., Ueno M., Kaneko N., Ono Y.
Organizer
11^<th> International Symposium on Proteinase Inhibitors and Biological Control
Place of Presentation
Portoroz, Slovenia
Year and Date
2008-09-02
-
-
-
