2010 Fiscal Year Final Research Report
Structural Interactome Studies from Computational and Bioinformatics Approaches
| Project/Area Number |
20370061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA Haruki Osaka University, 蛋白質研究所, 教授 (80134485)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Kengjo 東北大学, 大学院・情報科学研究科, 教授 (60332293)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGO Junichi 大阪大学, 蛋白質研究所, 特任研究員(客員教授) (80265719)
KAMIYA Narutoshi 大阪大学, 蛋白質研究所, 特任研究員(客員准教授) (80420462)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生物物理 / 蛋白質の構造・機能予測 / 生体分子 / プロテオーム / 分子動力学 / バイオインフォマティクス / データベース |
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| Research Abstract |
For structural interactome study, which investigates the protein-protein interaction network based on their tertiary structures, we have constructed several different kinds of databases and made informatics analyses by identifying and predicting the interfaces, so that complex structural models have been predicted. In addition, for the intrinsically denatured proteins, we have successfully reproduced and analyzed their coupled folding and binding procedures as the stable states in the free energy landscapes from computational studies.
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