2010 Fiscal Year Final Research Report
転写・RNAプロセシング・輸送の機能的連携と統合による遺伝子発現調節機構の解明
| Project/Area Number |
20370070
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
TANI Tokio Kumamoto University, 大学院・自然科学研究科, 教授 (80197516)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | スプライシング / 転写 / mRNA輸送 / 分裂酵母 / 遺伝子発現制御 |
|---|
| Research Abstract |
Recent emerging evidence suggested that a functional linkage among transcription, pre-mRNA splicing and nuclear mRNA export, which had been analyzed independently, exists in a living cell. However, the molecular mechanism of the linkage still remains unclear. In this study, we analyzed the genes responsible for the fission yeast mutations that cause defective pre-mRNA splicing and nuclear mRNA export, and elucidated a part of the molecular mechanism of coordinated regulation of gene expression in eukaryotic cells.
|
-
-
-
-
-
-
-
-
-
[Journal Article] S1-1 nuclear domains : characterization and dynamics as a function of transcriptional activity.2008
Author(s)
Akira Inoue, Katsuji Tsugawa, Kazuaki Tokunaga, KeniChiP. Takahashi, Shigehiko Uni, Masatsugu Kimura, Koji Nishio, Naoki Yamamoto, Ken-ichi Honda, Takanori Watanabe, Hideo Yamane, Tokio Tani.
-
Journal Title
Biology of the Cell 100
Pages: 523-535
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
