2010 Fiscal Year Final Research Report
Molecular mechanism that keep stem cells as a quiescent condition
| Project/Area Number |
20370089
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
OHTA Kunimasa Kumamoto University, 大学院・生命科学研究部, 准教授 (90244128)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 幹細胞 / 再生医学 / Tsukushi / Wnt |
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| Research Abstract |
We have reported that Tsukushi, which belongs to small leucine-rich proteoglycan family, functions as a novel Wnt signaling inhibitor at the extracellular region. We found that Tsukushi is expressed in the ciliary body in the eye, the subventricular zone in the lateral ventricles, the dentate gyrus in the hippocampus. In the Tsukushi KO mouse brain, the cell proliferation in the ciliary body and the subventricular zone were increase compared to wild type brain. Our data suggested that Tsukushi functions as a niche molecule for the regulation of neural stem/progenitor cells.
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