2010 Fiscal Year Final Research Report
Role of ubiquitin system in Xenopus gastrulation movements
| Project/Area Number |
20370090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | 原腸形成 / 細胞接着 / 細胞運動 |
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| Research Abstract |
Paraxial protocadherin(PAPC) has been shown to be involved in gastrulation cell movements during early embryogenesis. It is first expressed in the dorsal marginal zone at early gastrula stage and subsequently restricted to paraxial mesoderm during gastrulation in Xenopus and zebrafish. Using Xenopus embryos, we found that PAPC is regulated also at the protein level is degraded and excluded from the plasma membrane in the axial mesoderm at late gastrula stage. Our findings suggest a novel mechanism of regulation of a cell adhesion protein and that this system plays a crucial role in vertebrate embryogenesis.
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Research Products
(8 results)
