2011 Fiscal Year Final Research Report
Functional Analysis of a peptide regulator in epidermal morphogenesis
Project/Area Number |
20370091
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Kobe University (2011) National Institutes of Natural Sciences Okazaki Research Facilities (2008-2010) |
Principal Investigator |
KAGEYAMA Yuji 神戸大学, 自然科学系先端融合研究環遺伝子実験センター, 准教授 (90335480)
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Project Period (FY) |
2008 – 2011
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Keywords | ショウジョウバエ / 発生遺伝 / 上皮細胞 / 形態形成 / 細胞骨格 |
Research Abstract |
polished rice(pri) encodes extremely small 11 or 32 aa-long peptides that do notinclude any signatures of secretion signal peptide sequences, and therefore its gene products should be of novel type of bioactive molecules. To elucidate molecular mechanisms underlying pri function, we found prigenetically interacts with shavenbaby(svb). svbencodes a transcription factor and is hydrolysed and activated only in the presence of PRI peptides.
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[Journal Article] Small peptides switch the transcriptional activity of Shavenbaby during DrosophilaEmbryogenesis.2010
Author(s)
Takefumi Kondo, Plaza, S.,Zanet, J., Benrabah, E., Valenti, P., Hashimoto, Y., Kobayashi, S., Payre, F. and Kageyama, Y.
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Journal Title
Science
Volume: 329
Pages: 336-339
Peer Reviewed
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[Journal Article] MLE activates transcription via the minimal transactivation domain in Drosophila.2008
Author(s)
Satoko Aratani., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K. and Nakajima, T
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Journal Title
Int. J. Molec. Med.
Volume: 21
Pages: 469-476
Peer Reviewed
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