Evolution of sex-determining systems in vertebrates

2011 Fiscal Year Final Research Report

• Project/Area Number: 20370093
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Evolutionary biology
• Research Institution: Kitasato University
• Principal Investigator: ITO Michihiko 北里大学, 理学部, 准教授 (90240994)
• Co-Investigator(Kenkyū-buntansha): TAMURA Kei 北里大学, 理学部, 助教 (50458767)
• Project Period (FY): 2008 – 2011
• Keywords: 性決定遺伝子 / 脊椎動物 / 性染色体 / 生殖巣 / 遺伝子進化

Research Abstract

We analyzed and discussed sex-determining systems during vertebrate evolution, proposing a hypothesis that there might be a basic male sex-determining system driven by DMRT1 in non-mammalian vertebrates and that it might be changed into a SRY-SOX9 male sex-determining system during mammalian evolution. We also proposed a coevolution model of sex-determining genes and sex chromosomes, in which undifferentiated sex chromosomes easily allow replacement of a sex-determining gene with another new one, while specialized sex chromosomes are restricted a particular sex-determining gene.

Research Products

• [Journal Article] Molecular evolution of vertebrate sex-determining genes (2012)
  • Author(s): Mawaribuchi, S. Yoshimoto, S., Ohashi, S., Takamatsu, N. and Ito, M.
  • Journal Title: Chromosome Res Volume: 20 Pages: 139-151
  • DOI: DOI:10.1007/s10577-01109265-9
  • Peer Reviewed
• [Journal Article] A ZZ/ZW-type sex determination in Xenopus leavis (2011)
  • Author(s): Yoshimoto, S., and Ito, M.
  • Journal Title: FEBS J Volume: 278 Pages: 1020-1026
  • DOI: DOI:10.1111/j.1742-4658.2011.08031
  • Peer Reviewed
• [Journal Article] Opposite roles of DMRT1 and its W-linked paralogue DM-W, in sexual dimorphism of Xenopus laevis : Implications of a ZZ/ZW-type sex-determining system (2010)
  • Author(s): Yoshimoto, S., Ikeda, N., Izutsu, Y., Shiba, T., Takamatsu, N. and Ito, M.
  • Journal Title: Development Volume: 137 Pages: 2519-2526
  • DOI: DOI:10.1242/dev.048751
  • Peer Reviewed
• [Journal Article] Function and molecular evolution of mammalian Sox15, a singleton in the SoxG group of transcription factors (2010)
  • Author(s): Ito, M.
  • Journal Title: Int J. Biochem. Cell Biol Volume: 42 Pages: 449-452
  • DOI: DOI:10.1016/j.biocel.2009.10.023
  • Peer Reviewed
• [Journal Article] Xenopus W-linked DM-W induces Foxl2 and Cyp19 expression during ovary formation (2009)
  • Author(s): Okada, E., Yoshimoto, S., Ikeda, N., Kanda, H., Tamura, K., Shiba, T., Takamatsu, N., Ito, M.
  • Journal Title: Sex. Dev. Volume: 3 Pages: 38-42
  • DOI: DOI:10.1159/00020080
  • Peer Reviewed
• [Journal Article] アフリカツメガエルのZZ/ZW型性決定の分子機構-性決定システム進化- (2009)
  • Author(s): 伊藤道彦
  • Journal Title: 比較内分泌学 Volume: 35(134) Pages: 165-174
  • URL: https://www.jstage.jst.go.jp/article/nl2008jsce/35/134/35_134_165/_article/-char/ja/
• [Journal Article] アフリカツメガエルの性決定遺伝子DM-W.脊椎動物初の♀決定遺伝子 (2009)
  • Author(s): 伊藤道彦、吉本真
  • Journal Title: 生物の科学<遺伝> Volume: 63 Pages: 38-43
  • URL: http://ci.nii.ac.jp/naid/40016416603
• [Presentation] Opposite roles of DMRT1 and its W-linked paraloue the ZZ/ZW-type sex-determination in Xenopus laevis. (2011)
  • Author(s): Ito, M., Yoshimoto, S., Mawaribuchi, S., Ikeda, N., Fujitani, K., Tamura, K., and Takamatsu, N
  • Organizer: NASCE
  • Place of Presentation: Ann Arbor(USA)
  • Year and Date: 20110700
• [Presentation] Evolution of DMRT1-driven male sex-determining system (2010)
  • Author(s): Ito, M., Yoshimoto, S., Mawaribuchi, S., Ikeda, N., Takamatsu, N
  • Organizer: Society of Molecular Biology and Evolution
  • Place of Presentation: Lyon(France)
  • Year and Date: 20100700
• [Presentation] アフリカツメガエルWリンクの性(♀)決定遺伝子DM-W (2009)
  • Author(s): 伊藤道彦
  • Organizer: 第80回日本動学会大会
  • Place of Presentation: 静岡
  • Year and Date: 20090900
• [Presentation] A W-linked gene DM-W could induce female sex as a sex(ovary)-determining gene in Xenopus laevis that has the ZZ/ZW-type sex-determining system (2009)
  • Author(s): Ito, M., Yoshimoto, S., Takamatsu, N
  • Organizer: The 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong
  • Year and Date: 20090600
• [Presentation] A W-linked gene DM-W could determine female development as a sex(ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex determining system (2009)
  • Author(s): Ito, M., Yoshimoto, S., Takamatsu, N
  • Organizer: Fifth International Symposium on the biology of vertebrate sex determination
  • Place of Presentation: Hawaii(USA)
  • Year and Date: 20090400
• [Presentation] A W-linked DM-W is a likely sex(ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex-determining system (2008)
  • Author(s): Ito, M
  • Organizer: International Symposium for Gonad and Brain Sex Differentiation
  • Place of Presentation: Fukuoka
  • Year and Date: 20080900