2012 Fiscal Year Final Research Report
Basic research on the development of novel anticancer drugs utilizing bioactive substances from insects
| Project/Area Number |
20380039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
YAMAKAWA Minoru 独立行政法人農業生物資源研究所, 昆虫科学研究領域, 特任上級研究員 (30183677)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 昆虫 / 抗がん剤 / がん細胞 / 増殖抑制活性 / 新規化合物 / がん細胞増殖抑制メカニズム / タカサゴシロアリ |
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| Research Abstract |
The purpose of this study was to clarify the mode of action of beetle-derived antimicrobial peptides which attack some cancer cells but not normal cells. The peptides were revealed to electrostatically interact with negatively charged phosphatidylserine and disrupt the membrane of some cancer cells. On the other hand, a new compound, 1,1’-biphenyl-3,3’,4-triol was isolated and identified from a termite, Nasutitermes takasagoensis (Shiraki). This compound showed the suppressing activity of cancer cell proliferation, and the mode of action was suggested to be different from those of already-known anticancer drugs
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[Journal Article] Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphatidylserine on the cell surface2009
Author(s)
Iwasaki, T., Ishibashi, J., Saido-Sakanaka, H., Tanaka, H., Sato, M., Taylor, D. and Yamakawa, M
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Journal Title
Peptides
Volume: 30
Pages: 660-668
Peer Reviewed
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[Journal Article] Antibacterial and anticancer activity of diasteromeric 9-mer peptides derived from beetle defensins2009
Author(s)
Iwasaki, T., Ishibashi, J., Taanaka, H., Sato, M., Asaoka, A., Taylor, D. and Yamakawa, M
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Journal Title
Peptide Science
Volume: 2008
Pages: 51-59
Peer Reviewed
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[Journal Article] Antibacterial and anticancer activity of diasteromeric 9-mer peptides derived from beetle defensins2008
Author(s)
Iwasaki, T., Ishibashi, J., Saido-Sakanaka, H., Sato, M., Asaoka, A., Taylor, D. and Yamakawa, M
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Journal Title
Peptide Science
Volume: 2007
Pages: 79-82
Peer Reviewed
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