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2010 Fiscal Year Final Research Report

Target identification of vauolating compound, vicenistatin.

Research Project

  • PDF
Project/Area Number 20380065
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

USUI Takeo  University of Tsukuba, 大学院・生命環境科学研究科, 准教授 (60281648)

Co-Investigator(Renkei-kenkyūsha) KANOH Naoki  東北大学, 大学院・薬学研究科, 准教授 (40317293)
Project Period (FY) 2008 – 2010
Keywords液胞化 / 標的分子 / Chemical Biology
Research Abstract

Vicenistatin is an novel vacuolating compound, but its molecular mechanism has remained to be revealed. We found that vicenistatin interfered with the upstream factors of PIKfyve, a PI3P 5-kinase, or regulators involved in PI-turnover.

  • Research Products

    (6 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.2010

    • Author(s)
      Chinen T., Nagumo Y., Watanabe T., Imaizumi T., Shibuya M., Kataoka T., Kanoh N., Iwabuchi Y., Usui T.
    • Journal Title

      Toxicol. Lett. 199

      Pages: 341-356

    • Peer Reviewed
  • [Journal Article] Application of proteomic profiling based on 2-DIGE for classification of compounds according to the mechanism of action.2010

    • Author(s)
      Muroi M., Kazami S., Noda K., Kondo H., Takayama H., Kawatani M., Usui T., Osada H.
    • Journal Title

      Chem.Biol. 17

      Pages: 460-470

    • Peer Reviewed
  • [Presentation] 蛋白質-蛋白質相互作用阻害剤の解析2010

    • Author(s)
      臼井健郎
    • Organizer
      日本農芸化学会東北北海道支部合同第11回若手シンポジウム
    • Place of Presentation
      モンタナリゾート(宮城県)
    • Year and Date
      2010-11-26
  • [Presentation] マーカーレス遺伝子破壊によるフォワードケミカルバイオロジー研究に向けた薬剤超感受性酵母の作成と利用2010

    • Author(s)
      臼井健郎
    • Organizer
      酵母研究会
    • Place of Presentation
      小西酒造(株)(兵庫県)
    • Year and Date
      2010-03-09
  • [Book] Protein in Targeting with Small Molecules(Osada H.ed.)(Chapter 12 "Data on Small Molecules and Their Target Proteins")2009

    • Author(s)
      Usui T., Saito A., Osada H.
    • Total Pages
      239-276
  • [Remarks] ホームページ

    • URL

      http://www.sakura.cc.tsukuba.ac.jp/~usui/index/index.html

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Published: 2012-01-26   Modified: 2016-04-21  

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