2010 Fiscal Year Final Research Report
Immunoregulation by the gut commensal bacteria or probiotics
| Project/Area Number |
20380079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
KAMINOGAWA Shuichi Nihon University, 生物資源科学部, 教授 (50011945)
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| Co-Investigator(Kenkyū-buntansha) |
HOSONO Akira 日本大学, 生物資源科学部, 准教授 (70328706)
TAKAHASHI Kyoko 日本大学, 生物資源科学部, 講師 (70366574)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腸管 / 腸内共生菌 / 免疫 / 感染 / アレルギー |
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| Research Abstract |
Huge numbers of commensal bacteria colonize the gastrointestinal tract of mammals. These organisms play a key role in inducing the development and maintaining the homeostasis of the intestinal immune system. In this study, we have revealed that Bacteroides promote the development of the germinal center in the cecum, and induce total IgA production in the large intestine by increasing IgA^+B cells. Furthermore, we have demonstrated that intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate serum antibody responses induced by dietary antigens through modulation of the intestinal and systemic T cell phenotype by using germ-free mice.
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Research Products
(88 results)
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[Journal Article] Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients : randomized, double-blind, placebo-controlled study.
Author(s)
Itoh H, Uchida M, Sashihara T, Ji ZS, Li J, Tang Q, Ni S, Song L, Kaminogawa S
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Journal Title
Peer Reviewed
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[Presentation] Regulatory function of T cells with different expression pattern of CD62L/CD44, induced by oral administration of antigen.2009
Author(s)
MURAKAMI Hitoshi, HACHIMURA Satoshi, TANABE Kosuke, ADACHI(NAKAJIMA)Haruyo, TSUDA Masato, WAKATSUKI Yoshio, SATO Ryuichiro, TAKAHASHI Kyoko, HOSONO Akira, KAMINOGAWA Shuichi
Organizer
第39回日本免疫学会総会・学術集会
Place of Presentation
大阪
Year and Date
20091202-20091204
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[Presentation] CD3-IL-2R^+ Peyer's patch cells respond to microbial stimuli, migrate to the lamina propria, secrete IL-5, and induce IgA production.2009
Author(s)
UMEDA Yukiko, OGAWA Shimpei, KURAOKA Masayuki, TAKAHASHI Yoshimasa, ITOH Kikuji, YAMADA Kiyoshi, KOURO Taku, TSUJI Noriko M, HOSONO Akira, TOTSUKA Mamoru, TAKATSU Kiyoshi, KAMINOGAWA Shuichi, SATO Ryuichiro, HACHIMURA Satoshi
Organizer
The 14th International Congress of Mucosal Immunology (ICMI 2009)
Place of Presentation
Boston, Massachusetts, USA
Year and Date
20090705-20090709
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[Presentation] Comparison of Immunoglobulin A induction by commensal bacteria, Bacteroides and Lactobacillus.2008
Author(s)
Akihito Oyama, Akira Hosono, Tsutomu Yanagibashi, Masato Tsuda, Satoshi Hachimura, Yoshimasa Takahashi, Kikuji Itoh, Kazuhiro Hirayama, Kyoko Takahashi, Shuichi Kaminogawa
Organizer
The 21st Annual and International Meeting of the JAACT (JAACT 2008 Fukuoka)
Place of Presentation
Fukuoka, Japan
Year and Date
20081124-20081127
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