2010 Fiscal Year Final Research Report
Studies on the molecular mechanisms for Marek's disease virus to increase its virulence in the field
| Project/Area Number |
20380157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHASHI Kazuhiko Hokkaido University, 大学院・獣医学研究科, 教授 (90250498)
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| Co-Investigator(Kenkyū-buntansha) |
OCHIAI Kenji 北海道大学, 大学院・獣医学研究科, 准教授 (80214162)
KONNAI Satoru 北海道大学, 大学院・獣医学研究科, 准教授 (40396304)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 病原微生物 / マレック病 / マレック病ウイルス |
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| Research Abstract |
To clarify the molecular mechanisms for Marek's disease virus (MDV) to increase its virulence, several viral genes of MDV strains recently isolated from the field were analyzed. Diversities/polymorphisms were identified in one of the MDV genes, meq, that could be potentially related to the increase in MDV virulence. When we analyzed the effects of these diversities/polymorphisms in the meq gene on the functions of the meq gene product (Meq), the amino acid substitutions resulted from the diversities/polymorphisms significantly altered the transactivation and transforming activities of Meq. These findings suggest that the diversities/polymorphisms in the meq gene could contribute to the recent increase in MDV virulence in the field.
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Research Products
(25 results)
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[Journal Article] Serological survey of Toxoplasma gondii in wild waterfowl in chukotka, Kamchatka, Russia and Hokkaido, Japan2008
Author(s)
Murao T., Omata Y., Kano R., Murata S., Okada T., Konnai S., Asakawa M., Ohashi K., Onuma M.
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Journal Title
J.Parasitol. 94
Pages: 830-833
Peer Reviewed
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