2010 Fiscal Year Final Research Report
Postnatal carcinogenic risks of fetal stage exposure to environmental pollutants and its epigenetic molecular mechanism
| Project/Area Number |
20380168
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied veterinary science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
OHSAKO Seiichiroh The University of Tokyo, 大学院・医学系研究科, 准教授 (00274837)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYABARA Yuichi 信州大学, 山岳科学総合研究所, 准教授 (80311330)
|
|---|
| Research Collaborator |
TAKEDA Makio 残留農薬研究所, 毒性部, 室長
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 有害化学物質 / ゲノム / 発生・分化 / 環境 / 薬剤反応性 |
|---|
| Research Abstract |
Recently much attention is focused to the hypothesis that the fetal stage environments can influence health and disease after birth. Laboratory animals exposed to dioxin in the fetal stage are prone to cancer when they are administered carcinogens such as benzo[a]pyrene in adulthood. In the present study using mice, we demonstrated that the epigenetic memory including DNA methylation of the gene for CYP1A1 enzyme responsible for metabolic activation of carcinogens was altered by perinatal exposure to dioxin and revealed a part of molecular mechanism causing this alteration.
|
-
-
-
-
-
[Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease : In the spermatozoa stage or at fertilization?2010
Author(s)
Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
-
Journal Title
Reprod Toxicol 29
Pages: 68-73
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
