2010 Fiscal Year Final Research Report

An Etiologic and therapeutic study on canine necrotizing meningoencephalitis

Research Project

Project/Area Number	20380169
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Clinical veterinary science
Research Institution	The University of Tokyo
Principal Investigator	MATSUKI Naoaki The University of Tokyo, 大学院・農学生命科学研究科, 准教授 (40251417)
Project Period (FY)	2008 – 2010
Keywords	臨床病理 / 病態
Research Abstract	Genetic, etiologic and therapeutic studies were performed on canine mecrotizing meningoencephalitis (NME). The genetic study consisted of the determination of glial fibrillary acidic protein in the cerebrospinal fluids from Pug dogs in 4 families. As a result, NME was suggested to be an autosomal recessive disorder. By the etiologic studies, GFAP-antibody complexes and anti-transglutaminase autoantibodies were demonstrated in the NME cerebrospinal fluids. In the therapeutic study, three immunosuppressive protocols were examined on dogs with NME. No significant difference was observed in the survival times and neurological scores among the therapeutic protocols.