2010 Fiscal Year Final Research Report
Comparative analysis on metastasis-associated molecules in malignant tumors with different metastatic routes such as canine mammary cancer and osteosarcoma
| Project/Area Number |
20380170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SASAKI NOBUO The University of Tokyo, 大学院・農学生命科学研究科, 教授 (60107414)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMOTO Hajime 東京大学, 大学院・農学生命科学研究科, 教授 (60163804)
NISHIMURA Ryohei 東京大学, 大学院・農学生命科学研究科, 教授 (80172708)
MOCHIZUKI Manabu 東京大学, 大学院・農学生命科学研究科, 准教授 (90261958)
NAKAGAWA Takayuki 東京大学, 大学院・農学生命科学研究科, 助教 (40447363)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Hiroyuki 東京大学, 大学院・農学生命科学研究科, 教授 (40155891)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 犬骨肉腫 / 犬乳癌 / 細胞株 / ヌードマウス / 移植部位 / 増殖 / 肺転移 |
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| Research Abstract |
Difference in growth and metastasis was investigated using tumor a cell linetransplanted nude mice model receiving orthotopic and ectopic xenograft. In a canine osteosarcoma cell-xenografted model, growth and metastasis were significantly different depending on the xenografted site and ezrin expression was strongly related to metastasis in this mice model. In a canine mammary cancer model, there was no significant difference in the growth and metastasis depending on the xenografted sites, however VEGF (vascular endothelial growth factor) and NF-κB (nuclear factor κB) expressions were related to growth and metastasis in this mice model.
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