2010 Fiscal Year Final Research Report
Study of molecular mechanism of the ER quality control in plants
| Project/Area Number |
20380188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KOIZUMI Nozomu Osaka Prefecture University, 生命環境科学研究科, 教授 (20252835)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小胞体ストレス / シロイヌナズナ / 転写因子 / スプライシング / シャペロン |
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| Research Abstract |
If proteins with abnormal structures accumulate in the intracellular compartment called the endoplasmic reticulum (ER), such condition is transmitted to the nucleus causing activation of genes for chaperones that assist the correct folding of proteins. We found that a sensor protein IRE1 localizing on the ER membrane is involved in cytoplasmic splicing as the first report of cytoplasmic splicing in plants. It was considered that a membrane bound transcription factor bZIP60 was converted to active form losing its transmembrane domain by the splicing and translocated to the nucleus activating target genes.
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[Journal Article] NtbZIP60, an endoplasmic reticulum-localized transcription factor, plays a role in the defense response against bacterial pathogens in tobacco.2008
Author(s)
Tateda, C., Ozaki, R., Onodera, Y., Takahashi, Y., Yamaguchi, K., Berberich, T., Koizumi N., Kusano T.
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Journal Title
Journal of Plant Research 121
Pages: 603-611
Peer Reviewed
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