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2011 Fiscal Year Final Research Report

Neuro-immune cross talk with molecular imaging and medicine

Research Project

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Project/Area Number 20390015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionAichi Gakuin University

Principal Investigator

NAKANISHI Mamoru  愛知学院大学, 薬学部, 教授 (90090472)

Co-Investigator(Kenkyū-buntansha) FURUNO Tadahide  愛知学院大学, 薬学部, 准教授 (80254308)
INOH Yoshikazu  愛知学院大学, 薬学部, 講師 (90434547)
TESHIMA Reiko  国立医薬品食品衛生研究所, 代謝生化学部, 部長 (50132882)
Project Period (FY) 2008 – 2011
Keywords生物物理化学
Research Abstract

We developed a unique technique for studying neuro-immune interaction with confocal laser scanning fluorescence microscopy. We found that nerve-mast cell communication can occur in the absence of an intermediary transducing cell and that the neuropeptide substance P, operating via NK-1 receptors, is a soluble factor of this communication. In addition, we showed that ATP which is released from activated mast cells mediates the activation of nerve cells. Further, we found CADM1(cell adhesion molecule 1) play an important role of the communication between mast cells and nerve cells.

  • Research Products

    (15 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results) Book (1 results)

  • [Journal Article] A rational approach to inducing neuronal differentiation in embryonic stem cells, in Lovrecic, K.(Ed), Embryonic Stem Cells : The Hormonal Regulation of Pluripotency and Embryogenesis2011

    • Author(s)
      Furuno, T., Nakanishi, M.
    • Journal Title

      InTech

      Pages: 429-444

    • Peer Reviewed
  • [Journal Article] Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1, CADM12011

    • Author(s)
      Hagiyama, M., Furuno, T., Hosokawa, Y., Iino, T., Ito, T., Inoue, T., Nakanishi, M., Murakami, Y., Ito, A.
    • Journal Title

      J. Immunol.

      Volume: 186 Pages: 5983-5992

    • Peer Reviewed
  • [Journal Article] Analysis of neuro-immune interactions by an in vitro co-culture approach, in Merighi, A.(Ed), Neuropeptides : Methods and Protocols2011

    • Author(s)
      Furuno, T., Nakanishi, M.
    • Journal Title

      Methods in Molecular Biology

      Volume: vol.789 Pages: 171-180

    • Peer Reviewed
  • [Journal Article] Rapid delivery of small interfering RNA by biosurfactant MEL-A-containing liposomes2011

    • Author(s)
      Inoh, Y., Furuno, T., Hirashima, N., Kitamoto, D., Nakanishi, M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 414 Pages: 635-640

    • Peer Reviewed
  • [Journal Article] Complexin II regulates degranulation in RBL-2H3 cells by interacting with SNARE complex containing syntaxin-3.Cell2010

    • Author(s)
      Tadokoro, S., Nakanishi, M., Hirashima, N.
    • Journal Title

      Immunol

      Volume: 261 Pages: 51-56

    • Peer Reviewed
  • [Journal Article] Phosphorylation states of STAT3 and ERKs in mouse embryonic stem cells2010

    • Author(s)
      Miyazu, S., Furuno, T, Nakanishi, M.
    • Journal Title

      Cell Biol. Int

      Volume: 34 Pages: 485-492

    • Peer Reviewed
  • [Journal Article] The ratio of unsaturated fatty acids in biosurfactants affects the efficiency of gene transfection2010

    • Author(s)
      Inoh, Y., Furuno, T., Hirashima, N., Kitamoto, D., Nakanishi, M.
    • Journal Title

      Int. J. Pharm.

      Volume: 398 Pages: 225-230

    • Peer Reviewed
  • [Journal Article] Effect of NeuroD2 expression on neuronal differentiation in mouse embryonic stem cells2009

    • Author(s)
      Sugimoto, Y., Furuno, T., Nakanishi, M.
    • Journal Title

      Cell Biol. Int.

      Volume: 33 Pages: 174-179

    • Peer Reviewed
  • [Journal Article] Nano vectors with a biosurfactant for gene transfection and drug delivery(review)2009

    • Author(s)
      Nakanishi, M., Inoh, Y., Kitamoto, D., and Furuno, T.
    • Journal Title

      J. Drug Deliv. Sci. Tech.

      Volume: 19 Pages: 165-169

    • Peer Reviewed
  • [Journal Article] Molecular basis of neuroimmune interaction in an in vitro coculture approach(review)2008

    • Author(s)
      Nakanishi, M. and Furuno, T.
    • Journal Title

      Cell. Mol. Immunol.

      Volume: 5 Pages: 249-259

    • Peer Reviewed
  • [Presentation] バイオサーファクタント含有正電荷リソポームを用いたsiRNA細胞内導入ベクター開発2011

    • Author(s)
      伊納義和、古野忠秀、平嶋尚英、北本大、中西守
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
  • [Presentation] 神経・マスト細胞相互作用における接着分子CADM1の研究2011

    • Author(s)
      古野忠秀、伊藤彰彦、細川陽一郎、中西守
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
  • [Presentation] 共存培養系を用いた神経線維と膵臓α細胞の相互作用の解析2009

    • Author(s)
      古野忠秀、伊藤彰彦、中西守
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
  • [Presentation] 神経と膵臓α細胞の相互作用における接着分子CADM1の機能解析2008

    • Author(s)
      古野忠秀、伊藤彰彦、中西守
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-08-06
  • [Book] 薬品分析科学の最前線2009

    • Author(s)
      中西守、古野忠秀
    • Total Pages
      172-173
    • Publisher
      じほう

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Published: 2013-07-31  

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