2011 Fiscal Year Final Research Report
Neuro-immune cross talk with molecular imaging and medicine
| Project/Area Number |
20390015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FURUNO Tadahide 愛知学院大学, 薬学部, 准教授 (80254308)
INOH Yoshikazu 愛知学院大学, 薬学部, 講師 (90434547)
TESHIMA Reiko 国立医薬品食品衛生研究所, 代謝生化学部, 部長 (50132882)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 生物物理化学 |
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| Research Abstract |
We developed a unique technique for studying neuro-immune interaction with confocal laser scanning fluorescence microscopy. We found that nerve-mast cell communication can occur in the absence of an intermediary transducing cell and that the neuropeptide substance P, operating via NK-1 receptors, is a soluble factor of this communication. In addition, we showed that ATP which is released from activated mast cells mediates the activation of nerve cells. Further, we found CADM1(cell adhesion molecule 1) play an important role of the communication between mast cells and nerve cells.
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Research Products
(15 results)
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[Journal Article] Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1, CADM12011
Author(s)
Hagiyama, M., Furuno, T., Hosokawa, Y., Iino, T., Ito, T., Inoue, T., Nakanishi, M., Murakami, Y., Ito, A.
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Journal Title
J. Immunol.
Volume: 186
Pages: 5983-5992
Peer Reviewed
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