2010 Fiscal Year Final Research Report
Molecular mechanism of proteoglycan signalings
| Project/Area Number |
20390019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUGAHARA Kazuyuki Hokkaido University, 大学院・先端生命科学研究院, 教授 (60154449)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Shuhei 北海道大学, 大学院・先端生命科学研究院, 准教授 (70240017)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUMOTO Shuji 北海道大学, 大学院・先端生命科学研究院, 学術研究員 (40443973)
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| Project Period (FY) |
2008 – 2010
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| Keywords | グリコサミノグリカン / コンドロイチン硫酸 / デルマタン硫酸 / ヘパラン硫酸 / 神経突起 / 細胞増殖因子 / 計算科学 / プロテオグリカン |
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| Research Abstract |
The difference in the functions and regulatory mechanisms of heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (CS/DS) is still obscure. In the present study we analyzed molecular interactions between signaling molecules and the glycosaminoglycan (GAG) chains, especially CS/DS chains, to investigate the differences in the roles of HS and CS/DS in the signaling processes. Our results revealed that not only the sequences of disaccharide units but also the conformation of oligosaccharide domains and electrostatic distribution along the chains are important.
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[Journal Article] Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.2011
Author(s)
Baasanjav S., Al-Gazali L., Hashiguchi T., Mizumoto S., Fischer B., Horn D., Seelow D., Ali B.R., Aziz S.A.A., Langer R., Saleh A.A.H., Becker C., Nurnberg G., Cantagrel V., Gleeson J.G., Gomez D., Michel J.-B., Stricker S., Lindner T.H., Nurnberg P., Sugahara K., Mundlos S., Hoffmann K.
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Journal Title
Am.J.Hum.Genet. (in press.)
Peer Reviewed
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[Journal Article] Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome.2010
Author(s)
Miyake N., Kosho T., Mizumoto S., Furuichi T., Hatamochi A., Nagashima Y., Arai E., Takahashi K., Kawamura R., Wakui K., Takahashi J., Kato H., Yasui H., Ishida T., Ohashi H., Nishimura G., Shiina M., Saitsu H., Tsurusaki Y., Doi H., Fukushima Y., Ikegawa S., Yamada S., Sugahara K., Matsumoto N.
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Journal Title
Hum.Mutat.(Equal contribution) 31(8)
Pages: 966-974
Peer Reviewed
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[Journal Article] Important role of heparan sulfate in postnatal islet growth and insulin secretion.2009
Author(s)
Takahashi I., Noguchi N., Nata K., Yamada S., Kaneiwa T., Mizumoto S., Ikeda T., Sugihara K., Asano M., Yoshikawa T., Yamauchi A., Shervani N. J., Uruno A., Kato I., Unno M., Sugahara K., Takasawa S., Okamoto H., Sugawara A.
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Journal Title
Biochem.Biophys.Res.Commun. 383(1)
Pages: 113-118
Peer Reviewed
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[Presentation] The E-type structure of chondroitin sulfate on tumor cell surfaces is involved in lung and liver metastases.2010
Author(s)
Kazuyuki Sugahara, Fuchuan Li, Sengottuvelan Murugan, Basappa, Taishi Hashiguchi, Shuji Mizumoto, Shuhei Yamada, Kayoko Oguri, Minoru Okayama, Kazuki N.Sugahara, Chun Man Lee, Masayuki Miyasaka, Gerdy B.ten Dam, Toin H.van Kuppevelt
Organizer
Asian Communications of Glycobiology and Glycotechnology (ACGG)
Place of Presentation
Taipei
Year and Date
2010-10-27
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[Presentation] Cell surface chondroitin sulfate E type structure of mouse tumor cell lines is involved in the experimental metastasis to the lung and liver.2009
Author(s)
Kazuyuki Sugahara, Shuhei Yamada, Sengottuvelan Murugan, Fuchuan Li, Basappa, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama, Kazuki N. Sugahara, Chun Man Lee, Masayuki Miyasaka, Gerdy B.ten Dam, Toin H.van Kuppevelt
Organizer
6th international Conference on Proteoglycan
Place of Presentation
Aix-les-Bains, France
Year and Date
20090914-20090916
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