2010 Fiscal Year Final Research Report
Novel molecular functions of calcium-activated potassium channel as a target of drug development
| Project/Area Number |
20390027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IMAIZUMI Yuji Nagoya City University, 大学院・薬学研究科, 教授 (60117794)
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| Co-Investigator(Kenkyū-buntansha) |
OHYA Susumu 名古屋市立大学, 大学院・薬学研究科, 准教授 (70275147)
YAMAMURA Hisao 名古屋市立大学, 大学院・薬学研究科, 講師 (80398362)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAI Kiyofumi 名古屋市立大学, 大学院・医学研究科, 教授 (70212462)
HIGUCHI Tunehiko 名古屋市立大学, 大学院・薬学研究科, 教授 (50173159)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Ca^<2+>活性化K+チャネル / 非興奮性細胞 / 創薬ターゲット / 正帰還Ca^<2+>制御機構 / 非選択性陽イオンチャネル |
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| Research Abstract |
The present study revealed that functional expression of Ca^<2+>-activated K+ (BK, IK, SK) channels in non-excitable cells, such as chondrocytes, vascular endothelial cells and T-lymphocytes, substantially contributes to sustained increase in intracellular Ca^<2+> concentration in response to various types of stimuli. We proved that Ca^<2+>-activated K+ channels play the central roles in the positive feedback mechanism for the regulation of intracellular Ca^<2+> concentration via the membrane hyperpolarization, which increases the driving force of store-operated Ca^<2+> influx through non-selective cation channels.
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