2010 Fiscal Year Final Research Report
Suppression of platelet aggregation mediated by metastasis-promoting Aggrus protein
| Project/Area Number |
20390029
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Japanese Foundation For Cancer Research |
|---|
Principal Investigator |
FUJITA Naoya Japanese Foundation For Cancer Research, 癌化学療法センター基礎研究部, 部長 (20280951)
|
|---|
| Research Collaborator |
SATO Shigeo (財)癌研究会, 癌化学療法センター基礎研究部, 主任研究助手
TAKAMI Miho (財)癌研究会, 癌化学療法センター基礎研究部, 研究補助員
NAKAZAWA Youya (財)癌研究会, 癌化学療法センター基礎研究部, 研究生
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | Aggrus / podoplanin / 血小板凝集 / がん転移 |
|---|
| Research Abstract |
We have previously identified Aggrus protein as a metastasis-promoting platelet aggregation-inducing factor expressed on the surface of metastatic tumor cells. We established 5 different monoclonal antibodies (mAbs) recognizing human Aggrus protein and found that a mAb suppressed Aggrus-mediated platelet aggregation. We also identified a tetraspanin family CD9 protein as an Aggrus-inhibitory binding protein. Using in vivo imaging system, we successfully visualized the effect of CD9 on pulmonary metastasis and lung retention of GFP-expressing tumor cells.
|
-
-
[Journal Article] Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.2011
Author(s)
Shogo Ehata, Erik Johansson, Ryohei Katayama, Sumie Koike, Akira Watanabe, Yukari Hoshino, Yoko Katsuno, Akiyoshi Komuro, Daizo Koinuma, Mitsunobu R.Kano, Masakazu Yashiro, Kosei Hirakawa, Hiroyuki Aburatani, Naoya Fujita, Kohei Miyazono
-
Journal Title
Oncogene 30
Pages: 1693-1705
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
