2011 Fiscal Year Final Research Report
Development of drug candidates that epigenetically regulate gene expression
| Project/Area Number |
20390034
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
MIYATA Naoki 名古屋市立大学, 大学院・薬学研究科, 教授 (50114674)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Takayoshi 名古屋市立大学, 大学院・薬学研究科, 講師 (90372838)
NAKAGAWA Hidehiko 名古屋市立大学, 大学院・薬学研究科, 准教授 (80281674)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Keywords | エピジェネティクス / 遺伝子発現制御 / 創薬分子設計 / ヒストン脱メチル化酵素阻害剤 / ヒストン脱アセチル化酵素阻害薬 |
|---|
| Research Abstract |
Chromatin remodeling, caused by histone modifications, plays a crucial role in the regulation of epigenetic gene expression. Histone deacetylase(HDAC) and histone demethylase(HDME) were selected as target enzymes. Isozyme selective and highly active inhibitors against these enzymes were designed and synthesized. HDAC8, SIRT and HDAC3 selective and JMJD2, PHF8, LSD1 selective inhibitors were developed.
|
