2012 Fiscal Year Final Research Report
Studies on synthetic antioxidants for prevention of oxidative stress-related diseases
| Project/Area Number |
20390038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
FUKUHARA Kiyoshi 国立医薬品食品衛生研究所, 有機化学部, 室長 (70189968)
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| Co-Investigator(Kenkyū-buntansha) |
OKUDA Haruhiro 国立医薬品食品衛生研究所, 副所長 (30160807)
UMEMURA Takashi 国立医薬品食品衛生研究所, 病理部, 室長 (50185071)
OHNO Akiko 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 (70356236)
SYODA Takuji 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 (60435708)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 抗酸化剤 / カテキン / 酸化ストレス / アルツハイマー病 |
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| Research Abstract |
The development of antioxidants with strong radical-scavenging activities has attracted considerable attention in recent years for preventing oxidative stress related diseases. We focused on the chemical modification of natural catechin to improve its pharmacological properties with the aim of developing clinically useful chemopreventive agents. Treatment of catechin with ketone by way of an Oxa-Pictet-Spengler reaction enabled the structure of catechin to be planar. Thus synthesized planar catechin analogues showed strong antioxidative activity. We also synthesized catechin analogues (CN) having nynhidrin structure. These catechin analogues significantly blocked the self-aggregation of s-amyloid and reduced the neuronal viability loss evoked by s-amyloid.
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[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers2013
Author(s)
Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
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Journal Title
J Clin Biochem Nutr
Volume: 52
Pages: 133-138
DOI
Peer Reviewed
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[Journal Article] Kinetics and Mechanism for the Scavenging Reaction of the 2,2-Diphenyl-1-picrylhydrazyl Radical by Synthetic Artepillin C Analogues2012
Author(s)
T. Kawashima, S. Manda, Y. Uto, K. Ohkubo, H. Hori, K. Matsumoto, K. Fukuhara, N. Ikota, S. Fukuzumi, T. Ozawa, K. Anzai, I. Nakanishi
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Journal Title
Bull. Chem. Soc. Jpn.
Volume: 85
Pages: 877-883
DOI
Peer Reviewed
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[Journal Article] Intramolecular base-accelerated radicalscavenging reaction of a planar catechin derivative having a lysine moiety2009
Author(s)
K. Fukuahra, I. Nakanishi, K. Ohkubo, Y. Obara, A. Tada, K. Imai, A. Ohno, A. Nakamura, T. Ozawa, S. Urano, S. Saito, S. Fukuzumi, K. Anzai, N. Miyata, H. Okuda
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Journal Title
Chem. Comm.
Pages: 6180-6182
DOI
Peer Reviewed
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[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
Author(s)
K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
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Journal Title
Chem. Res. Toxicol
Volume: 21
Pages: 282-287
DOI
Peer Reviewed
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