2010 Fiscal Year Final Research Report
Research of transporter-adaptor network as target of drug effect and toxicity
| Project/Area Number |
20390047
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
KATO Yukio Kanazawa University, 薬学系, 教授 (30251440)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100)
|
|---|
| Research Collaborator |
NAKAMICHI Noritaka 金沢大学, 薬学系, 准教授 (10401895)
SUGIURA Tomoko 金沢大学, 薬学系, 助教 (70542190)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | トランスポーター / アダプター / 薬物動態 / 生体膜透過 / タンパク質間相互作用 |
|---|
| Research Abstract |
Transporters are the membrane proteins involved in permeation of drug molecules across plasma membranes. Although they are assumed to play fundamental roles in drug absorption and disposition, little information is available on their direct association with drug efficacy and toxicity. Therefore, the aim of the present study was to clarify pharmacokinetic, pharmacodynamic and toxicodynamic roles of transporters by focusing on their adaptor proteins which have already been clarified by our previous studies. As the final results of this grant, we have clarified (i) the roles of carnitine/organic cation transporters (OCTNs) in drug disposition and efficacy in small intestine, liver, kidney and heart, (ii) the roles of influx and efflux transporters in gastrointestinal drug absorption, and (iii) direct interaction and regulation of three intestinal influx transporters by an adaptor protein PDZK1.
|
-
[Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine.2010
Author(s)
Sugiura T, Otake T, Shimizu T, Wakayama T, Silver DL, Utsumi R, Nishimura T, Iseki S, Nakamichi N, Kubo Y, Tsuji A, Kato Y.
-
Journal Title
Drug Metab Pharmacokinet 25(5)
Pages: 588-598
-
[Journal Article] Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.2010
Author(s)
Sugiura T, Kato S, Shimizu T, Wakayama T, Nakamichi N, Kubo Y, Iwata D, Suzuki K, Soga T, Asano M, Iseki S, Tamai I, Tsuji A, Kato Y.
-
Journal Title
Drug Metab Dispos 38(10)
Pages: 1665-1672
-
[Journal Article] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.2010
Author(s)
Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A.
-
Journal Title
Pharm Res 27(5)
Pages: 832-840
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
