2010 Fiscal Year Final Research Report
Investigation of clinical impacts of CNV in the pharmacokinetic-related genes
| Project/Area Number |
20390048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
IEIRI Ichiro Kyushu University, 大学院・薬学研究院, 教授 (60253473)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Takeshi 九州大学, 大学院・薬学研究院, 助教 (80423573)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薬物動態 / 遺伝子 / コピー数多型 / CNV / 薬剤反応性 |
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| Research Abstract |
We developed a new method for the analysis of CNV, and analyzed of CNV in PK/PD-related genes in healthy volunteers and NSCLC patients. The new method, using real-time PCR and calibrator vector, was high-throughput to determine the absolute copy number, and it was expected to suit for the clinical diagnosis. But, it is necessary to take account of the localization of target sequence of primer and probes. We detected some new CNV in PK/PD related genes. As the result of the analysis in detail, some may change the function of the gene. The clinical impacts of CNV should be cleared by further investigations.
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[Journal Article] Novel large-scale deletion (whole exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome.2009
Author(s)
Kanda D, Takagi H, Kawahara Y, Yata Y, Takakusagi T, Hatanaka T, Yoshinaga T, Iesaki K, Kashiwabara K, Higuchi T, Mori M, Hirota T, Higuchi S, Ieiri I.
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Journal Title
Drug Metab Pharmacokinet. 24(5)
Pages: 464-468
Peer Reviewed
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