2010 Fiscal Year Final Research Report
Novel C-terminus-specific functions of the APC protein
| Project/Area Number |
20390055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
SENDA Takao Fujita Health University, 医学部, 教授 (10187875)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Ryuji 藤田保健衛生大学, 医学部, 講師 (20325161)
SHIMOMURA Atsushi 藤田保健衛生大学, 医学部, 講師 (50340237)
HASEGAWA Yoshimi 藤田保健衛生大学, 医学部, 講師 (40288494)
KOGO Akiko 藤田保健衛生大学, 医学部, 助教 (20340242)
OHKUMA Mahito 藤田保健衛生大学, 医学部, 講師 (50329710)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
MIYACHI Ei-Ichi 藤田保健衛生大学, 医学部, 教授 (90129685)
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| Research Collaborator |
ONOUCHI Takanori 藤田保健衛生大学, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Keywords | APC / PSD-95 / 脳形成 / 細胞分化 / 遺伝子改変マウス / 行動解析 |
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| Research Abstract |
APC(adenomatous polyposis coli)was originally identified as a tumor suppressor protein. In the present study, we investigated functions of the APC regions except for the βcatenin-binding domain. Systemic behavior tests revealed schizophrenia-like behavior disorders of APC1638T mice which lack the C-terminus of APC. APC1638T mice showed morphological abnormalities of the hippocampal pyramidal neuron spines and conduction defects of the synapses. Also, distributions of monoamines in the APC1638T mouse brain altered. These disorders of APC1638T mice may cause their schizophrenia-like behavior.
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Research Products
(48 results)
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[Journal Article] Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads.2010
Author(s)
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K
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Journal Title
Endocrinology 151
Pages: 5893-5904
Peer Reviewed
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[Journal Article] Expression of vascular endothelial growth factor and presence of angiovascular cells in tissue from different thyroid disorders.2010
Author(s)
Itoh A, Iwase K, Jimbo S, Yamamoto H, Yamamoto N, kokubo M, Senda T,, Nakai A, Nagasaka A, Nagasaka T, Hibi Y, Seko T
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Journal Title
World J Surg 34
Pages: 242-248
Peer Reviewed
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[Journal Article] Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma.2008
Author(s)
Ono Y, Oda N, Ishihara S, Shimomura A, Hayakawa N, Suzuki A, Horiguchi A, Senda T,, Miyakawa S, Itoh M
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Journal Title
Eur J Endocrinol 159
Pages: 81-86
Peer Reviewed
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[Journal Article] The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function.
Author(s)
Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Oda N, Fodde R, Itoh M, Senda T
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Journal Title
Med Mol Morphol (in press)
Peer Reviewed
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