Function of food-entrainable clock neurons in the dorsomedial hypothalamic nucleus

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390056
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Kanazawa University
• Principal Investigator: MIEDA Michihiro Kanazawa University, 医学系, 准教授 (20296552)
• Project Period (FY): 2008 – 2011
• Keywords: 概日リズム / 摂食 / 視床下部 / マウス / ニューロン

Research Abstract

毎日固定した一定時間帯でのみ餌が得られる環境下(時間的食餌制限)では、動物は給餌前数時間にわたり食物探索行動を示し、給餌時間内に十分量摂食するように順応する。この食餌同期性概日行動リズムは、哺乳類の概日リズム制御中枢・視交叉上核(SCN)とは別の生物時計(食餌同期性クロック)によって制御される。我々は以前、視床下部背内側核(DMH)が食餌同期性クロックの有力な候補部位であることを見いだした。食餌同期性クロックは環境、生活習慣への適応、不適応のメカニズムを理解する上で重要であると考え、本研究ではDMH食餌同期性クロック(DOMFEC)ニューロンを突破口とし、食餌同期性概日リズム制御の神経メカニズムを明らかにすることを目的とする。

Research Products

• [Journal Article] Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory. (2011)
  • Author(s): Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T.
  • Journal Title: PLoS One 24 Pages: e16972
  • Peer Reviewed
• [Journal Article] The orexin system : roles in sleep/wake regulation. (2010)
  • Author(s): Sakurai T, Mieda M, Tsujino N.
  • Journal Title: Ann N Y Acad Sci. 1200 Pages: 149-161
  • Peer Reviewed
• [Journal Article] Integrative physiology of orexins and orexin receptors. (2009)
  • Author(s): Mieda M, Sakurai T.
  • Journal Title: CNS Neurol Disord Drug Targets. 8 Pages: 281-295
  • Peer Reviewed
• [Journal Article] Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.
  • Author(s): Mieda M, Hasegawa E, Kisanuki YY, Sinton, CM, Yanagisawa M, Sakurai T.
  • Journal Title: J.Neurosci.corresponding author in press
  • Peer Reviewed
• [Journal Article] Connectomics of Orexin-producing Neurons : Interface of Systems of Emotion, Energy Homeostasis and Arousal.
  • Author(s): Sakurai T, Mieda M.
  • Journal Title: Trends Pharmacol.Sci. in press
  • Peer Reviewed
• [Presentation] Extra-SCN expression of BMAL1 in the ventral forebrain generates the precise circadian pattern of locomotor activity. (2011)
  • Author(s): Mieda M, Hasegawa E, Kessaris N, Tanaka K, Sakurai T.
  • Organizer: 第116回日本生理学会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 20110300
• [Presentation] Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. (2011)
  • Author(s): Hasegawa E, Mieda M, Kisanuki YY, Sinton, CM, Yanagisawa M, Sakurai T.
  • Organizer: 第116回日本生理学会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 20110300
• [Presentation] Pharmacogenetic modulation of orexin neurons alters behavioral states in mice. (2011)
  • Author(s): Sasaki K, Suzuki M, Mieda M, Sakurai T.
  • Organizer: 第116回日本生理学会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 20110300
• [Presentation] Functional and histological interaction between preoptic area GABAergic neurons and orexin neurons. (2011)
  • Author(s): Tsujino N, Saito Y, Hondo M, Mieda M, Sakurai T.
  • Organizer: 第116回日本生理学会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 20110300
• [Presentation] Both OX1R and OX2R orexin receptors mediate efferent signals of orexin neurons in eliciting food-anticipatory activity. (2009)
  • Author(s): Abe T, Mieda M, Tanaka K, Yanagisawa M, Sakurai T.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2009-07-29