2011 Fiscal Year Final Research Report
Function of food-entrainable clock neurons in the dorsomedial hypothalamic nucleus
| Project/Area Number |
20390056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Takeshi 金沢大学, 医学系, 教授 (60251055)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 概日リズム / 摂食 / 視床下部 / マウス / ニューロン |
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| Research Abstract |
When food availability is temporally restricted to a fixed time of the day(restricted feeding), animals adapt to this condition within a few days by feeding during the period of food availability and increasing food-seeking activity in the preceding hours. These changes in biological rhythms have been postulated to be brought about by a food-entrainable oscillator(FEO) that is independent of the mammalian master clock in the suprachiasmatic nucleus(SCN), although little is known of the physical and molecular substrates of the FEO. In this study, we demonstrated that an SCN-independent FEO in the nervous system requires a clock gene, Bmal1, and plays a critical role in adaptation of circadian locomotor activity and food intake to restricted feeding.
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[Journal Article] Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory2011
Author(s)
Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T
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Journal Title
PLoS One
Volume: 24
Pages: e16972
Peer Reviewed
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