2010 Fiscal Year Final Research Report
Clarification of molecular mechanisms of abnormal vascular contraction by functional proteomics and a single molecular analysis of signal transduction
| Project/Area Number |
20390059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KOBAYASHI Sei Yamaguchi University, 大学院・医学系研究科, 教授 (80225515)
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| Co-Investigator(Kenkyū-buntansha) |
KISHI Hiroko 山口大学, 大学院・医学系研究科, 講師 (40359899)
KAJIYA Katsuko 山口大学, 大学院・医学系研究科, 助教 (00379942)
KAWAMICHI Hozumo 山口大学, 大学院・医学系研究科, 助教 (80363042)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 病態生理 / 血管病 / 1分子 / シグナル伝達 / 機能的プロテオミクス |
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| Research Abstract |
We tried to clarify the molecular mechanisms of abnormal vascular contraction by functional proteomics and a single molecular analysis of signal transduction. We identified some candidates for novel signaling molecules for abnormal vascular contraction. We found that myosin light chain are phosphorylated by Rho-kinase in the absence of Ca2+ and can rapid sliding with actin. We observed the interaction between SPC and lipid raft model membrane.
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[Journal Article] Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage : A possible role as a spasmogen.2009
Author(s)
T.Kurokawa, Y.Yumiya, H.Fujisawa, S.Shirao, S.Kashiwagi, M.Sato, H.Kishi, S.Miwa, K.Mogami, S.Kato, T.Akimura, M.Soma, K.Ogasawara, A.Ogawa, S.Kobayashi, M.Suzuki
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Journal Title
J Clin Nuerosci 16
Pages: 1064-1068
Peer Reviewed
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