Clarifying the mechanisms involved in modification of autonomic- and behavioral-thermoregulations during dehydration

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390066
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Waseda University
• Principal Investigator: NAGASHIMA Kei Waseda University, 人間科学学術院, 教授 (40275194)
• Project Period (FY): 2008 – 2011
• Keywords: 浸透圧 / 行動性体温調節 / 正中視索前野 / 視床下部 / オペラント行動 / 脱水 / 快不快感 / 体温調節

Research Abstract

脱水時の体温調節の抑制の神経メカニズムを明らかにすること。これは動物を用いた生理学的実験と組織科学的実験で行う。報酬行動システムを用いて明らかにされた動物の高浸透圧負荷時の行動性体温調節の亢進がヒトにおいても認められるかを検証する。高浸透圧負荷時に認められた行動性体温調節の亢進の神経機構を明らかにすることである。これには新たな報酬行動システムの開発と生理学的、組織科学的実験を含む。これらの実験をもとに最終的には、脱水時の体温調節の変化が、従来言われているような、体温調節中枢のセットポイント体温の上昇、として説明できるか否かを結論づけることである。

Research Products

• [Journal Article] Estrogen in the medial preoptic nucleus of the hypothalamus modulates cold responses in female rats. (2010)
  • Author(s): Uchida Y, Tokizawa K, Nakamura M, Mori H, Nagashima K
  • Journal Title: Brain Research 21,1339 Pages: 49-59
  • Peer Reviewed
• [Journal Article] Mild hypohydration induced by exercise in the heat attenuates autonomic thermoregulatory responses to the heat, but not thermal pleasantness in humans. (2010)
  • Author(s): Tokizawa K, Yasuhara S, Nakamura M, Uchida Y, Crawshaw LI, Nagashima K
  • Journal Title: Physiology and Behavior 100 Pages: 340-345
  • Peer Reviewed
• [Journal Article] Estrogen modulates central and peripheral responses to cold in female rats. (2010)
  • Author(s): Uchida Y, Kano M, Yasuhara S, Kobayashi A, Tokizawa K, Nagashima K.
  • Journal Title: Journal of Physiological Science 60 Pages: 151-160
  • Peer Reviewed
• [Journal Article] Concepts to utilize in describing thermoregulation and neurophysiological evidence for how the system works (2009)
  • Author(s): Kanosue K, Crawshaw LI, Nagashima K, Yoda T.
  • Journal Title: European Journal of Applied Physiology 109 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Kato F Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses.
  • Author(s): Ono K, Tsukamoto-Yasui M, Hara-Kimura Y, Inoue N, Nogusa Y, Okabe Y, Nagashima K
  • Journal Title: Journal of Applied Physiology. in press
  • Peer Reviewed
• [Presentation] Ghrelin modulates circadian thermoregulation via hypothalamic mechanisms (2010)
  • Author(s): Tokizawa K, Onoue Y, Uchida Y, Mori H, Nakamura M, Nagashima K.
  • Organizer: Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 20101000
• [Presentation] Effect of tail-hiding behavior on thermoregulation in fasted rats in the cold (2010)
  • Author(s): Uchida Y, Tokizawa K, Nakamura M, Nagashima K.
  • Organizer: 2010 Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-10-07
• [Presentation] エネルギーと体温調節反応(絶食時の体温概日リズム変調のメカニズム) (2010)
  • Author(s): 永島計
  • Organizer: 第25回臨床体温研究会
  • Place of Presentation: 札幌
  • Year and Date: 2010-08-28
• [Presentation] 摂食・体温調節と生体リズム (2010)
  • Author(s): 永島計
  • Organizer: 日本睡眠学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-02
• [Presentation] The central system plays an important role in the modulation of circadian rhythm, thermoregulation, and sports performance (2009)
  • Author(s): Nagashima K.
  • Organizer: Taiwan Sports Science Symposium
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2009-03-28
• [Book] ナップ(体温II、井上芳光、近藤徳彦(編)) (2010)
  • Author(s): 永島計
  • Total Pages: 142-155
• [Book] 体温とは、中枢での温度受容機構、末梢での温度受容機構、冷え性 ; からだと温度の事典、彼末一之(監修) (2010)
  • Author(s): 永島計
  • Total Pages: 2-10(152-154)
  • Publisher: 朝倉書店