2011 Fiscal Year Final Research Report
Comprehensive Analysis of the mechanism involved in changes of thermoregulatory responses during dehydration
| Project/Area Number |
20390066
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Waseda University |
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Principal Investigator |
NAGASHIMA Kei 早稲田大学, 人間科学学術院, 教授 (40275194)
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| Co-Investigator(Kenkyū-buntansha) |
KANOSUE Kazuyuki 早稲田大学, スポーツ科学学術院, 教授 (50127213)
TOKIZAWA Ken 早稲田大学, スポーツ科学学術院, 教授 (00454083)
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| Research Collaborator |
UCHIDA Yuki 早稲田大学, 人間科学学術院, 大学院生
LIN Chen_hsien 早稲田大学, スポーツ科学学術院, 大学院生
MATSUDA Mayumi (NAKAMURA Mayumi) 早稲田大学, 人間科学総合研究センター, 客員研究員
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| Project Period (FY) |
2008 – 2011
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| Keywords | 体温調節 / 行動性体温調節 / 暑熱逃避行動 / 温熱的快不快感 / 温熱感覚 / オペラント行動 / 血漿浸透圧 / 視床下部 |
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| Research Abstract |
Dehydration is a factor deteriorating autonomic thermoregulatory responses, which could induce heat stroke. However, the central mechanism remains unclear yet. Moreover, we do not know about the influence of dehydration on behavioral thermoregulation. In the present study, we clarified that the median preoptic nucleus in the hypothalamus is important as the receptor site of plasma osmolality, and it suppresses thermal reception of the median preoptic nucleus(thermal reception site in the central). The heat escape/cold seeking behavior in mice is suppressed in the condition of dehydration, and thermal sensation to heat was also decreased in dehydrated humans. These results indicate a possible mechanism involved in heat stroke.
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