2010 Fiscal Year Final Research Report
Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseases
| Project/Area Number |
20390071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YABE Chihiro Kyoto Prefectural University of Medicine, 医学研究科, 教授 (70150571)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Aki 筑波技術大学, 保健科学部, 特任教授 (20323298)
IWATA Kazumi 京都府立医科大学, 大学院・医学研究科, 講師 (60305571)
KATSUYAMA Masato 京都府立医科大学, 大学院・医学研究科, 准教授 (60315934)
松野 邦晴 京都府立医科大学, 大学院・医学研究科, 助教 (50420708)
KAKEHI Tomoko 京都府立医科大学, 大学院・医学研究科, プロジェクト研究員 (20433279)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖尿病 |
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| Research Abstract |
Induction of hyperglycemia with streptozotocin up-regulated the expression of NOX1, a novel isoform of superoxide-generating NADPH oxidase in the kidney. NOX1 derived ROS were shown to increase oxidative stress and to activate p38 MAPK, thereby stimulating renal redox-sensitive signaling under diabetic conditions.
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[Journal Article] The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme : Possible involvement of the ERK1/2-JunB pathway.2008
Author(s)
Cevik MO, Katsuyama M, Kanda S, Kaneko T, Iwata K, Ibi M, Matsuno K, Kakehi T, Cui W, Sasaki M, Yabe-Nishimura C.
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Journal Title
Biochem Biophys Res Commun 374
Pages: 351-355
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