2010 Fiscal Year Final Research Report
Influences of genetic and environmental factors on schizophrenia
| Project/Area Number |
20390073
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAMIYA Takayoshi 名城大学, 薬学部, 助教 (70340297)
NIWA Minae , 日本学術振興会・特別研究員 (60469046)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
MOURI Akihiro 名古屋大学, グローバルCOE, 特任助教 (20597851)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 統合失調症 / 行動学 / 遺伝子 / ストレス / 神経化学 |
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| Research Abstract |
Genetic susceptibility factors for adult psychiatric illnesses such as DISC1 influence adult high brain functions. Here we report the potential to generate an animal model via in utero gene transfer to address how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia. We show that transient knockdown of DISC1 in the pre- and perinatal stages, specifically in the prefrontal cortex, leads to selective abnormalities in postnatal mesocortical dopaminergic maturation and behavioral abnormalities after puberty.
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