2010 Fiscal Year Final Research Report
Research on tissue regeneration regulated by Met/HGF receptor ON-OFF regulation
| Project/Area Number |
20390077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
MATSUMOTO Kunio Kanazawa University, がん研究所, 教授 (90201780)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Takahiro 金沢大学, がん研究所, 助教 (70414018)
SAKAI Katsuya 金沢大学, がん研究所, 助教 (10523318)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞増殖因子 / HGF / 組織再生 / 受容体 / 再生医学 |
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| Research Abstract |
HGF-Met pathway participates in tissue regeneration. We found that phosphorylation of Ser985 in the Met receptor regulated dynamics and translocalization of Met, thereby regulating HGF-dependent Met activation. Ser985 phosphorylation was regulated upon liver injury, in a reciprocal manner to Met activation. Phosphorylation and dephosphorylation of Met-Ser985 regulated by tissue injury and intactness may play a role to suppress over-regeneration.
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[Journal Article] Induction of donor-specific tolerance using superagonistic CD28 antibody in rat renal allografts: Regulatory T-cell expansion before engraftment may be important.2011
Author(s)
Azuma H, Isaka Y, Nomi H, Inamoto T, Li XK, Hounig T, Takabatake Y, Ichimaru N,Ibuki N, Matsumoto K, Ubai T, Katsuoka Y, Takahara S.
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Journal Title
Transplantation 90(12)
Pages: 1328-1335
Peer Reviewed
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[Journal Article] Cellular injury of cardiomyocytes during hepatocyte growth factor gene transfection with ultrasound-triggered bubble liposome destruction.2011
Author(s)
Komamura, K., Tatsumi, R., Tsujita-Kuroda, Y., Onoe, T., Matsumoto, K., Nakamura, T., Miyazaki, J., Horio, T., Sugimachi, M.
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Journal Title
J.Drug Delivery 2011
Pages: 1-8
Peer Reviewed
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[Journal Article] NK4, an HGF ntagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells.2009
Author(s)
Kubota T, Fujiwara H, Matsumura A, Taiyoh H, Ichikawa I, Okamoto K, Matsumoto M, Nakamura T, Otsuji E.
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Journal Title
Clin.Exp.Metastasis 26
Pages: 447-456
Peer Reviewed
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[Journal Article] Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regression via tumor-specific T-lymphocyte activation.2009
Author(s)
Kubota T, Taiyoh H, Matsumura A, Murayama Y, Ichikawa D, Okamoto O, Fujiwara H, Ikoma H, Nakanishi N, Kikuchi S, Ochiai T, Sakakura C, Kokuba Y, Suzuki Y,Matsumoto K, Nakamura T, Otsuji E.
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Journal Title
Int.J.Cancer. 125
Pages: 2879-2886
Peer Reviewed
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[Journal Article] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.2009
Author(s)
Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Ooshio T, Nakada M, Sawamoto K, Matsumoto K, Oshima M, Asano M, Saya H, Okano H,Suda T, Hamada J, Hirao A.
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Journal Title
Proc.Natl Acad.Sci.USA 106(40)
Pages: 17163-17168
Peer Reviewed
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[Journal Article] Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with EGF Receptor activating mutations.2008
Author(s)
Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, Ogino H, Kakiuchi S, Hanibuchi M, Nishioka Y, Uehara H, Mitsudomi T, Yatabe Y, Nakamura T, Sone S.
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Journal Title
Cancer Res. 68
Pages: 9479-9487
Peer Reviewed
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[Journal Article] Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice.2008
Author(s)
Ito W, Tanimoto M, Ono K, Mizuno S, Yoshida A, Koga H, Fuchimoto Y, Kondo N, Tanimoto Y, Kiura K, Matsumoto K, Kataoka M, Nakamura T, Gelfand E, Kanehiro A.
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Journal Title
Int.Arch.Allergy Immunol. 145
Pages: 324-339
Peer Reviewed
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[Journal Article] Reduction of fibrosis in a rat model of non-alcoholic steatohepatitis cirrhosis by human HGF gene transfection using electroporation.2008
Author(s)
Kiyama S, Yamada T, Iwata H, Sekino T, Matsuo H, Yoshida N, Miyahara T, Umeda Y, Matsuno Y, Kimura M, Matsumoto K, Nakamura T, Takemura H.
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Journal Title
J.Gastroenterol.Hepatol. 23
Pages: e471-476
Peer Reviewed
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