• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Analysis of cell fate determination of vertebrate retinal photoreceptor cells

Research Project

  • PDF
Project/Area Number 20390087
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionOsaka Bioscience Institute

Principal Investigator

FURUKAWA Takahisa  Osaka Bioscience Institute, 発生生物学部門, 研究部長 (50260609)

Project Period (FY) 2008 – 2010
Keywords発生医学
Research Abstract

Vision is critical to our lives. To elucidate molecular mechanisms underlying development of retinal photoreceptor cells is not only important for biology but also for development of diagnosis and treatment of retinal diseases. We studied mechanisms of retinal photoreceptor development mainly by using mouse genetics. We progressed our understanding on molecular mechanisms underlying retinal stem cell proliferation, differentiation and maintenance of photoreceptor cells, function and related human diseases of bipolar cells.

  • Research Products

    (58 results)

All 2011 2010 2009 2008 Other

All Journal Article (25 results) (of which Peer Reviewed: 17 results) Presentation (30 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 網膜視細胞の機能構築-細胞運命・シナプスと繊毛の形成・ヒト疾患2011

    • Author(s)
      加藤君子,荒木章之,大森義裕,古川貴久
    • Journal Title

      実験医学 29

      Pages: 514-520

  • [Journal Article] SMOC1 is essential for ocular and limb development in humans and mice.2010

    • Author(s)
      Okada I., Furukawa T.
    • Journal Title

      Am.J.Hum.Genet. 88

      Pages: 1-12

    • Peer Reviewed
  • [Journal Article] Negative Regulation of ciliary length by ciliary ale germ cell-associated kinase (Mak) isrequired for retinal photoreceptor survival.2010

    • Author(s)
      Omori Y., Furukawa T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107

      Pages: 22671-22676

    • Peer Reviewed
  • [Journal Article] Negative Regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.2010

    • Author(s)
      Omori Y., Furukawa T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107

      Pages: 22671-22676

    • Peer Reviewed
  • [Journal Article] Plasticity of TRPM 1 expression and localization in the wild type and degenerating mouse retina.2010

    • Author(s)
      Krizaj D., Huang W., Furukawa T., Punzo C., Xing W.
    • Journal Title

      Vision Research 50

      Pages: 2460-2465

    • Peer Reviewed
  • [Journal Article] Sumoylation controls retinal progenitor proliferation by repressing cell cycle exit in Xenopus laevis.2010

    • Author(s)
      Terada K., Furukawa T.
    • Journal Title

      Developmental Biology 347

      Pages: 180-194

    • Peer Reviewed
  • [Journal Article] Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization.2010

    • Author(s)
      Kanagawa M., Furukawa T.
    • Journal Title

      J.Biol.Chem. 285

      Pages: 31208-31216

    • Peer Reviewed
  • [Journal Article] Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.2010

    • Author(s)
      Katoh K., Omori Y., Onishi A., Sato S., Kondo M., Furukawa T.
    • Journal Title

      J.of Neurosci. 30

      Pages: 6515-6526

    • Peer Reviewed
  • [Journal Article] TRPM1 mutations are associated with the complete form of congenital stationary night blindness.2010

    • Author(s)
      Nakamura M., Furukawa T.
    • Journal Title

      Mol.Vision 16

      Pages: 425-437

    • Peer Reviewed
  • [Journal Article] Secreted factor FAM3C (ILEI) is involved in retinal laminar formation.2010

    • Author(s)
      Katahira, T., Nakagiri, S., Terada, K., Furukawa T.
    • Journal Title

      BBRC 392

      Pages: 301-306

    • Peer Reviewed
  • [Journal Article] Gene expression analysis of embryonic photoreceptor precursor cells using BAC-Crx-EGFP transgenic mouse.2010

    • Author(s)
      Muranishi Y., Sato S., Inoue T., Ueno S., Koyasu T., Kondo M., Furukawa T.
    • Journal Title

      BBRC 392

      Pages: 317-322

    • Peer Reviewed
  • [Journal Article] TRPM1 : a vertebrate TRP channel responsible for retinal ON bipolar function.2010

    • Author(s)
      Koike C., Numata T., Ueda H., Mori Y., Furukawa T.
    • Journal Title

      Cell Calcium 48

      Pages: 95-101

  • [Journal Article] 眼疾患と動物モデル網膜・視神経疾患動物モデルの網膜電図解析2010

    • Author(s)
      近藤峰生,古川貴久
    • Journal Title

      日本眼科学雑誌 114

      Pages: 248-279

  • [Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.2010

    • Author(s)
      Koike C., Furukawa T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107

      Pages: 332-337

    • Peer Reviewed
  • [Journal Article] Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.2009

    • Author(s)
      Sanuki R., Omori Y., Koike C., Sato S., Furukawa T.
    • Journal Title

      FEBS Letters 584

      Pages: 753-758

    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.2009

    • Author(s)
      Kanamoto T., Mizuhashi K., Terada K., Minami T., Yoshikawa H., Furukawa T.
    • Journal Title

      BMC Developmental Biology 9

      Pages: 70

    • Peer Reviewed
  • [Journal Article] Retina Specific GTPase Accelerator RGS11/Gβ5S/R9AP is a Constitutive Heterotrimer Selectively Targeted to mGluR6 in ON-Bipolar Neurons.2009

    • Author(s)
      Cao Y., Furukawa T.
    • Journal Title

      J.of Neurosci. 29

      Pages: 9301-9313

    • Peer Reviewed
  • [Journal Article] Elevated Intraocular Pressure, Optic Nerve Atrophy, and Impaired Retinal Development in ODAG Transgenic Mice.2009

    • Author(s)
      Sasaki T., Furukawa T.
    • Journal Title

      IOVS 50

      Pages: 242-248

    • Peer Reviewed
  • [Journal Article] 網膜シナプスの高次構造を形作る細胞外マトリックス蛋白質ピカチュリン2009

    • Author(s)
      佐藤茂,不仁門尚,古川貴久
    • Journal Title

      神経眼科 26

      Pages: 439-446

  • [Journal Article] シナプスの高次構造をかたちづくる細胞外マトリッックス蛋白質ピカチュリン2009

    • Author(s)
      加藤君子,大森義裕,古川貴久
    • Journal Title

      蛋白質核酸酵素 54

      Pages: 1166-1172

  • [Journal Article] 網膜の視細胞における繊毛タンパク質の輸送機構と疾患2009

    • Author(s)
      大森義裕,古川貴久
    • Journal Title

      細胞工学 28

      Pages: 1036-1041

  • [Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.2008

    • Author(s)
      Sato, S., Furukawa T.
    • Journal Title

      Nat.Neurosci. 11

      Pages: 923-931

    • Peer Reviewed
  • [Journal Article] Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase, Rab8.2008

    • Author(s)
      Omori Y., Furukawa T.
    • Journal Title

      Nat.Cell Biol. 10

      Pages: 437-444

    • Peer Reviewed
  • [Journal Article] 繊毛におけるタンパク質輸送機構とRab GTPaseのつながり2008

    • Author(s)
      大森義裕,古川貴久
    • Journal Title

      実験医学 26

      Pages: 1744-1747

  • [Journal Article] 網膜視細胞の細胞極性と細胞内オルガネラの制御-外節形成、繊毛内輸送2008

    • Author(s)
      小池千恵子,古川貴久
    • Journal Title

      核のポジショニングから網膜変成症まで 80

      Pages: 224-232

  • [Presentation] TRPM1 : a vertebrate TRP channel responsible for retinal ON bipolar function2011

    • Author(s)
      沼田朋大
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-29
  • [Presentation] Role of ON-Direction Selective Ganglion Cells of Mouse Retina in Optokinetic Responses2011

    • Author(s)
      杉田祐子
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-28
  • [Presentation] 網膜の細胞運命決定、シナプスと繊毛の形成の分子制御2011

    • Author(s)
      古川貴久
    • Organizer
      東京大学大学院医学系研究科「医学共通講義III機能生物学」
    • Place of Presentation
      東京大学
    • Year and Date
      2011-02-14
  • [Presentation] 網膜研究による中枢神経系の構築機構の解明~細胞分化からシナプス形成まで~2010

    • Author(s)
      古川貴久
    • Organizer
      富山大学大学院特別セミナー
    • Place of Presentation
      富山大学
    • Year and Date
      2010-12-13
  • [Presentation] Molecular control of retinal photoreceptor cell fate and cilia formation, Pfizer2010

    • Author(s)
      古川貴久
    • Place of Presentation
      Pfizer, San Francisco, U.S.A.
    • Year and Date
      2010-11-22
  • [Presentation] Molecular control of retinal photoreceptor cell fate and morphogenesis2010

    • Author(s)
      古川貴久
    • Organizer
      UCA Neuroscience Seminar
    • Place of Presentation
      UCLA, U.S.A.
    • Year and Date
      2010-11-18
  • [Presentation] マウスおよびヒト網膜ON双極細胞におけるTRPM1-Lチャネルの機能解析2010

    • Author(s)
      古川貴久
    • Organizer
      視覚科学フォーラム
    • Place of Presentation
      筑波大学
    • Year and Date
      2010-08-26
  • [Presentation] 網膜の発生と機能の分子機構~遺伝情報による神経回路の作られ方2010

    • Author(s)
      古川貴久
    • Organizer
      第5回感覚器シンポジウム
    • Place of Presentation
      臨床研究(感覚器)センター
    • Year and Date
      2010-03-11
  • [Presentation] 網膜の発生と機能の分子機構~遺伝情報による神経回路の作られ方2010

    • Author(s)
      古川貴久
    • Organizer
      大阪大学生命機能研究交流会
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-02-26
  • [Presentation] Sumoylation controls retinal progenitor proliferation by repressing cell cycle exit in Xenopus2010

    • Author(s)
      古川貴久
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego Convention Center, U.S.A.
    • Year and Date
      2010-01-14
  • [Presentation] 網羅的遺伝子解析によって同定した網膜視細胞形成に関わる遺伝子群の解析2009

    • Author(s)
      古川貴久
    • Organizer
      「統合脳」冬のシンポジウム
    • Place of Presentation
      学術総合センター
    • Year and Date
      2009-12-19
  • [Presentation] 転写抑制因子による視細胞の運命決定と分化の制御機構2009

    • Author(s)
      古川貴久
    • Organizer
      第2回Retina Research Meeting
    • Place of Presentation
      東京大学
    • Year and Date
      2009-12-12
  • [Presentation] Molecular control of photoreceptor cell development by Otx2 transcription factor2009

    • Author(s)
      古川貴久
    • Organizer
      OIST Workshop
    • Place of Presentation
      OIST Seaside house
    • Year and Date
      2009-11-10
  • [Presentation] 中枢神経系において特異的に高発現する網膜非コードRNA3(RNCR3)の機能解析2009

    • Author(s)
      古川貴久
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸ポートビアホテル
    • Year and Date
      2009-10-22
  • [Presentation] Functional Analysis of TRPM1 in Visual Signal Transmission of Retinal ON Bipolar Cells2009

    • Author(s)
      古川貴久
    • Organizer
      ISOCB 2009
    • Place of Presentation
      Vila Gale Ericeira Hotel, Portugal
    • Year and Date
      2009-09-10
  • [Presentation] Sumoylation-activity of Ubc9 controls retinal progenitor proliferation by repressing the cell cycle exit in Xenopus laevis2009

    • Author(s)
      古川貴久
    • Place of Presentation
      University of Oxford
    • Year and Date
      2009-09-05
  • [Presentation] 網羅的遺伝子解析によって同定した網膜視細胞形成に関する遺伝子群の解析2009

    • Author(s)
      古川貴久
    • Organizer
      「統合脳」夏のワークショップ
    • Place of Presentation
      北海道厚生年金会館
    • Year and Date
      2009-08-12
  • [Presentation] Functional Development of Retinal Bipolar Cells2009

    • Author(s)
      古川貴久
    • Organizer
      The 18th CDB Meeting
    • Place of Presentation
      神戸理化学研究所
    • Year and Date
      2009-04-15
  • [Presentation] 網羅的遺伝子発現解析による網膜視細胞発生機構の解明2009

    • Author(s)
      古川貴久
    • Organizer
      犬山共同利用研究会「個体レベル比較生物学をめざして」
    • Place of Presentation
      犬山国際観光センター
    • Year and Date
      2009-03-06
  • [Presentation] 網羅的遺伝子解析によって同定した網膜視細胞形成に関する遺伝子群の解析2008

    • Author(s)
      加藤君子
    • Organizer
      「統合脳」冬のシンポジウム
    • Place of Presentation
      一ツ橋学術総合センター
    • Year and Date
      2008-12-14
  • [Presentation] 網膜視細胞の発生機構2008

    • Author(s)
      古川貴久
    • Organizer
      第81回日本生化学大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2008-12-11
  • [Presentation] 新規細胞外マトリックス蛋白質pikachurinによる網膜シナプス形成機構2008

    • Author(s)
      古川貴久
    • Organizer
      第6回日本糖鎖科学コンソーシアムシンポ
    • Place of Presentation
      東京コンファレンスセンター
    • Year and Date
      2008-12-03
  • [Presentation] 網膜視細胞のシナプス形成機構2008

    • Author(s)
      古川貴久
    • Organizer
      Retina Research Meeting
    • Place of Presentation
      順天堂大学
    • Year and Date
      2008-11-08
  • [Presentation] 網膜視細胞発生の分子コントロール~細胞運命からシナプス形成へ~2008

    • Author(s)
      古川貴久
    • Organizer
      日本学術振興会回折構造生物第169委員会第27回研究会
    • Place of Presentation
      京都大学
    • Year and Date
      2008-10-28
  • [Presentation] Molecular control of vertebrate retinal development~From cell fate determination to synapse formation~2008

    • Author(s)
      古川貴久
    • Organizer
      BSIセミナー
    • Place of Presentation
      和光理化学研究所
    • Year and Date
      2008-10-09
  • [Presentation] Roles of OTX2 and its downstream factors in developmental and functional construction of the vertebrate retina2008

    • Author(s)
      古川貴久
    • Organizer
      ICER 2008
    • Place of Presentation
      Beijing Wuzhou Crown Plaza Hotel, China
    • Year and Date
      2008-09-29
  • [Presentation] An essential role of pikachurin in photoreceptor ribbon synapse formation2008

    • Author(s)
      古川貴久
    • Organizer
      ISOCB 2008
    • Place of Presentation
      Paradise Point, San Diego, California, USA
    • Year and Date
      2008-09-04
  • [Presentation] 網膜双極細胞に発現するTRPM1の機能解析2008

    • Author(s)
      古川貴久
    • Organizer
      第12回視覚科学フォーラム
    • Place of Presentation
      大阪大学
    • Year and Date
      2008-08-28
  • [Presentation] 網膜ON型双極細胞におけるTRPM1の機能解析2008

    • Author(s)
      小池千恵子
    • Organizer
      第4回TRP研究会「TRPチャンネルの機能的多様性とその統一的理解」
    • Place of Presentation
      岡崎カンファレンスセンター
    • Year and Date
      2008-06-05
  • [Presentation] Molecular control of vertebrate retinal development~From cell fate determination to synapse formation~2008

    • Author(s)
      古川貴久
    • Organizer
      熊本大学グローバルCOEリエゾンラボ研究会
    • Place of Presentation
      熊本大学
    • Year and Date
      2008-04-23
  • [Book] 入門構造生物学-放射光X線と中性子で最新の生命現象を読み解く2010

    • Author(s)
      古川貴久, 他
    • Total Pages
      240
    • Publisher
      高エネルギー加速器研究機構構造生物学センター
  • [Remarks] ホームページ等

    • URL

      http://www.obi.or.jp/dept4/index.html

  • [Patent(Industrial Property Rights)] 骨芽細胞分化誘導因子遺伝子及びその利用2010

    • Inventor(s)
      古川貴久
    • Industrial Property Rights Holder
      大阪バイオサイエンス研究所
    • Industrial Property Number
      特許,特願第2008-133591
    • Acquisition Date
      2010-05-21

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi