2010 Fiscal Year Final Research Report
Elucidation for crosstalk of the nuclear-cytoplasic signalling in the apoptotic response to oxidative stress
| Project/Area Number |
20390091
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOSHIDA Kiyotsugu Tokyo Medical and Dental University, 難治疾患研究所, 准教授 (70345312)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アポトーシス / 酸化ストレス / レドックス制御 / がん治療 |
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| Research Abstract |
Oxidative stress has been implicated in the initiation and development of many diseases and causes a various types of cellular injury, including DNA and protein damage, lipid peroxidation, and damage to other biomolecules. Oxidative stress also occurs during apoptotic cell death. We have shown that several pro-apoptotic kinases including PKCdelta, c-Abl, and DYRK2 undergo nuclear-cytoplasmic shuttling in response to oxidative stress. Importantly, whereas precise regulation for the shuttling of these kinases remain uncertain, this mechanism has consequences for induction of apoptosis and implies that proper localization is central to the function of pro-apoptotic kinases. These findings highlight recent efforts on molecular medicine demonstrating that the nuclear targeting of kinases is novel and essential regulatory mechanisms that directly influences the induction of apoptosis in response to oxidative stress.
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