2010 Fiscal Year Final Research Report
Relationship between inflammation and novel NF-κB activation pathway which is regulated by ubiquitin system
| Project/Area Number |
20390097
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
TOKUNAGA Fuminori Osaka University, 医学系研究科, 准教授 (00212069)
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| Co-Investigator(Kenkyū-buntansha) |
IWAI Kazuhiro 大阪大学, 大学院・生命機能研究科, 教授 (60252459)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子腫瘍学 / 蛋白質 / 酵素 / 細胞・組織 / 炎症 / ユビキチン |
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| Research Abstract |
We identified LUBAC ubiquitin ligase, which composed of SHARPIN, HOIL-1L, and HOIP, forms a novel type of linear polyubiquitin chain. LUBAC regulates NF-κB system, a critical transcription factor for inflammation and immune regulation. Furthermore, we revealed that cpdm mice, which lack Sharpen by a spontaneous mutation, induce dermatitis by the reduction of LUBAC and NF-κB activity. These results indicate that linear polyubiquitination is an indispensable post-transcription modification for NF-κB activation.
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[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.2011
Author(s)
Ikeda F., Deribe Y.L, Skanland S.S., Stieglitz B., Grabbe C., van WijK S., Franz-Wachtel M., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J.P., Schaefer L., Macek B., Rittinger K., Dikic, I.
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Journal Title
Nature 471
Pages: 637-641
Peer Reviewed
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[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-κB activation.2009
Author(s)
Tokunaga F., Sakata S.-i., Saeki Y., Satomi Y., Kirisako T., Kamei K., Nakagawa T., Kato M., Murata S., Yamaoka S., Yamamoto M., Akira S., Takao T., Tanaka K., Iwai K.
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Journal Title
Nature Cell Biol. 11
Pages: 123-132
Peer Reviewed
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