2011 Fiscal Year Final Research Report
Molecular targets for lung adenocarcinoma with epithelial-mesenchymal transition : identification and their application for diagnosis and therapy.
| Project/Area Number |
20390103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
NIKI Toshiro 自治医科大学, 医学部, 教授 (90198424)
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| Co-Investigator(Kenkyū-buntansha) |
MATSYBARA Daisuk 自治医科大学, 医学部, 助教 (80415554)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 肺癌 / 分子標的 |
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| Research Abstract |
The major findings of this project are summarized as follows :(1) loss of chromatin remodeling factors, BRG1 and BRM, were closely correlated with and may be involved in EMT of lung adenocarcinomas ;(2) CTGF(connective tissue growth factor) was identified as a biomarker of lung adenocarcinomas with EMT features ; and (3) lung adenocarcinomas with EMT features were sensitive to cisplatin or one of the inhibitors for HDAC, Hsp 90, Proteasome, and Jak2.
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