2010 Fiscal Year Final Research Report
Roles of novel target genes of Cdx1/2 in differentiation and transformation of intestinal epithelial cells.
| Project/Area Number |
20390110
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyoto University |
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Principal Investigator |
AOKI Masahiro Kyoto University, 分子病態学部, 部長 (60362464)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 大腸癌 / 転写因子 / 短鎖脂肪酸 / GEF |
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| Research Abstract |
Expression of the Slc5a8 gene encoding a short-chain fatty acid transporter was positively regulated by Cdx1/2 in vivo, and its level was reduced in the colonic polyps of Apc mutant mice, accompanied by decreased expression of Cdx2. Plekhg1 was shown to be a direct target gene of Cdx1/2. Plekhg1 was involved in E-cadherin-mediated cell-cell adhesion, and bound to 14-3-3 only when phosphorylated at serine 611.
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