2010 Fiscal Year Final Research Report
Role of T cells in the innate immune response during sepsis
| Project/Area Number |
20390111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Okayama University |
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Principal Investigator |
MATSUKAWA Akihiro Okayama University, 大学院・医歯薬学総合研究科, 教授 (90264283)
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Yasumasa 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30403489)
HIDA Akira 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10435026)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Masato 独立行政法人理化学研究所, チームリーダー (40277281)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 敗血症 / 自然免疫 / サイトカイン / シグナル伝達 |
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| Research Abstract |
T cells exist in the peritoneum under healthy conditions. Rag2Ko mice (T and B cell deficient) showed increased mortality rate during sepsis, which was recovered after adoptive transfer of T cells, but not B cells. Mice with overexpression of SOCS5 in T cells (SOCS5-cTg) demonstrated increased Th1 response in the peritoneum whereas SOCS3-cTg mice exhibited decreased systemic inflammatory response during septic peritonitis, leading to the increased survival rate during sepsis. Thus, T cells appear to be important in innate immunity, which can be controlled by SOCS3/5 in T cells. We also elucidated the crucial roles of T cells in different types of inflammation models, such as T cell-dependent hepatitis and arthritis.
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[Journal Article] Galectin-9 expands immunosuppressive macrophages to ameliorate T cell- mediated lung inflammation.2010
Author(s)
Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, Hirashima M.
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Journal Title
Eur J Immunol. 40
Pages: 548-558
Peer Reviewed
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[Journal Article] Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages.2009
Author(s)
Arikawa T, Watanabe K, Seki M, Matsukawa A, Oomizu S, Sakata K, Sakata A, Ueno M, Saita N, Niki T, Yamauchi A, Hirashima M.
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Journal Title
Clin.Immunol. 133
Pages: 382-392
Peer Reviewed
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[Journal Article] Galectin-9 accelerates Transforming Growth Factor 3-induced differentiation of human mesenchymal stem cells to chondrocytes.2009
Author(s)
Arikawa T, Matsukawa A, Watanabe K, Sakata K, Seki M, Nagayama M, Takeshita K, Ito K, niki T, Oomizu S, Shinonaga R, Saita N, Hirashima M.
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Journal Title
Peer Reviewed
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[Journal Article] Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.2008
Author(s)
Seki M, Oomizu S, Sakata K, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M.
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Journal Title
Clin. Immunol. 127
Pages: 78-88
Peer Reviewed
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