2011 Fiscal Year Final Research Report
Regulation of proteolysis on epithelial cell membrane and its implication in the epithelial disorders
| Project/Area Number |
20390114
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Naoki 熊本大学, 生命資源・研究支援センター, 教授 (90304998)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Hiroyuki 宮崎大学, 医学部, 助教 (90433060)
FUKUSHIMA Tsuyoshi 宮崎大学, 医学部, 助教 (10452913)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 分子 / プロテアーゼ |
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| Research Abstract |
Pericellular proteolysis has critical roles in homeostasis and disease progression in multicellular organisms. We analyzed roles for hepatocyte growth factor activator inhibitor type 1(HAI-1), a membrane-bound serine protease inhibitor expressed on the epithelial cell surface, and its target proteases(HGF activator, matriptase, etc) in processing of pericellular bioactive molecules, epithelial integrity, carcinogenesis and cancer progression. Our data uncovered critical roles of HAI-1 in normal regulated keratinization of epidermal keratinocytes, formation of hair cuticle and intestinal epithelial integrity. We also found that HAI-1 may be an important suppressor of epithelial carcinogenesis and cancer invasion.
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