2010 Fiscal Year Final Research Report
Role of heterocellular gap-junctional communication between cardiomyocytes and myofibroblasts in genesis of ventricular tachy arrhytymias
| Project/Area Number |
20390115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKAMATSU Tetsuro Kyoto Prefectural University of Medicine, 医学研究科, 教授 (40154900)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Hideo 京都府立医科大学, 大学院・医学研究科, 准教授 (60236619)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 不整脈 / 心筋梗塞 / 非心筋細胞 / ギャップ結合 |
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| Research Abstract |
This study addressed the possibility that myofibroblasts (MF), produced during healing phase of myocardial infarct, play important role(s) in fatal ventricular tachyarrhythmias. In scrape loading of the left ventricular wall, neurobiotin loaded into the cardiomyocytes (CM) propagated to the surrounding MF via Cx43. CM culture of neonate revealed slower conduction of the CM tissue co-cultured with MF in the opposite side of the filter membrane cup. Arrhythmogenic depolzizations were observed in CM layer when MFs were cultured in filter-membrane on the opposite side. Taken together, MF plays important role in arrhythmias during MI.
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